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A majority of cancer cells showed weak cytoplasmic staining or were negative. Several renal, prostate, testicular, ovarian and colorectal cancers displayed moderate immunoreactivity.
GENE INFORMATION
Gene name
TNFAIP6 (HGNC Symbol)
Synonyms
TSG-6, TSG6
Description
Tumor necrosis factor, alpha-induced protein 6 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]
