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Most cancers showed moderate to strong cytoplasmic staining. Lymphomas and several cases of gliomas were weakly stained or negative.
GENE INFORMATION
Gene name
KCNJ2 (HGNC Symbol)
Synonyms
IRK1, Kir2.1, LQT7
Description
Potassium channel, inwardly rectifying subfamily J, member 2 (HGNC Symbol)
Entrez gene summary
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. [provided by RefSeq, Jul 2008]