Cell atlas - SLC12A4 - The Human Protein Atlas

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SLC12A4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Endosomes

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	SLC12A4
Gene description	Solute carrier family 12 (potassium/chloride transporter), member 4
Protein class	FDA approved drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endosome.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Endosomes (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA041138
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endosome.

Main location

Endosomes (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041138	A-431	Endosomes
	HPA041138	U-2 OS	Endosomes
	HPA041138	U-251 MG	Endosomes

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA041138	U-2 OS	Image	SLC12A4 localizes to retromers, as it partially co-localizes with the retromer marker VPS26A.

GENE INFORMATION
Gene name	SLC12A4 (HGNC Symbol)
Synonyms	KCC1
Description	Solute carrier family 12 (potassium/chloride transporter), member 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	67943474 - 67969601
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124067 (version 83.38)
Entrez gene	6560
UniProt	Q9UP95 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UP95
Antibodypedia	SLC12A4 antibodies

PROTEIN BROWSER

SLC12A4-001	SLC12A4-004	SLC12A4-005	SLC12A4-007	SLC12A4-008	SLC12A4-017	SLC12A4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC12A4-001 ENSP00000318557 ENST00000316341	Q9UP95 [Direct mapping] Solute carrier family 12 member 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006821 [chloride transport] GO:0006884 [cell volume homeostasis] GO:0007268 [synaptic transmission] GO:0010107 [potassium ion import] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019901 [protein kinase binding] GO:0022820 [potassium ion symporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	1085 aa 120.6 kDa	No	>9
SLC12A4-004 ENSP00000438334 ENST00000541864	Q9UP95 [Direct mapping] Solute carrier family 12 member 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006821 [chloride transport] GO:0006884 [cell volume homeostasis] GO:0007268 [synaptic transmission] GO:0010107 [potassium ion import] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019901 [protein kinase binding] GO:0022820 [potassium ion symporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	1054 aa 117 kDa	No	>9
SLC12A4-005 ENSP00000445962 ENST00000537830	Q9UP95 [Direct mapping] Solute carrier family 12 member 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006821 [chloride transport] GO:0006884 [cell volume homeostasis] GO:0007268 [synaptic transmission] GO:0010107 [potassium ion import] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019901 [protein kinase binding] GO:0022820 [potassium ion symporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	1079 aa 119.6 kDa	No	>9
SLC12A4-007 ENSP00000461403 ENST00000572037	I3L4N6 [Direct mapping] Solute carrier family 12 member 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0006811 [ion transport] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	1037 aa 115.1 kDa	No	>9
SLC12A4-008 ENSP00000464168 ENST00000571299	J3QRE2 [Direct mapping] Solute carrier family 12 member 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	178 aa 18.8 kDa	No	6
SLC12A4-017 ENSP00000458902 ENST00000576616	Q9UP95 [Direct mapping] Solute carrier family 12 member 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006821 [chloride transport] GO:0006884 [cell volume homeostasis] GO:0007268 [synaptic transmission] GO:0010107 [potassium ion import] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019901 [protein kinase binding] GO:0022820 [potassium ion symporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	1068 aa 118.6 kDa	No	>9
SLC12A4-201 ENSP00000395983 ENST00000422611	Q9UP95 [Direct mapping] Solute carrier family 12 member 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006821 [chloride transport] GO:0006884 [cell volume homeostasis] GO:0007268 [synaptic transmission] GO:0010107 [potassium ion import] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019901 [protein kinase binding] GO:0022820 [potassium ion symporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	1087 aa 119.7 kDa	No	>9

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.