Fields »
ABOUT
HELP
BLOG
MC3R

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 MC3R

Gene description

 Melanocortin 3 receptor

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 MC3R (HGNC Symbol)

Synonyms

 MC3

Description

 Melanocortin 3 receptor (HGNC Symbol)

Entrez gene summary

 This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.2

Chromosome location (bp)

 56248732 - 56249815

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124089 (version 83.38)

Entrez gene

 4159

UniProt

 P41968 (UniProt - Evidence at protein level)

neXtProt

 NX_P41968

Antibodypedia

 MC3R antibodies

PROTEIN BROWSER
MC3R-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MC3R-001
ENSP00000243911
ENST00000243911
P41968 [Direct mapping]
Melanocortin receptor 3
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0002027 [regulation of heart rate]
GO:0004930 [G-protein coupled receptor activity]
GO:0004977 [melanocortin receptor activity]
GO:0004980 [melanocyte-stimulating hormone receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0008217 [regulation of blood pressure]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0032922 [circadian regulation of gene expression]
GO:0042309 [homoiothermy]
GO:0042923 [neuropeptide binding]
GO:0045475 [locomotor rhythm]
GO:0055078 [sodium ion homeostasis]
GO:0060259 [regulation of feeding behavior]
Show all
 323 aa
36 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.