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CTCFL

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GENERAL INFORMATION

Gene name

 CTCFL

Gene description

 CCCTC-binding factor (zinc finger protein)-like

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transcription factors

Predicted localization

 Intracellular,Membrane

Number of transcripts

 16
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (K-562, HMC-1)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (K-562, HMC-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CTCFL (HGNC Symbol)

Synonyms

 BORIS, CT27, dJ579F20.2

Description

 CCCTC-binding factor (zinc finger protein)-like (HGNC Symbol)

Entrez gene summary

 CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Chromosome

 20

Cytoband

 q13.31

Chromosome location (bp)

 57495966 - 57525652

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124092 (version 83.38)

Entrez gene

 140690

UniProt

 Q8NI51 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NI51

Antibodypedia

 CTCFL antibodies

PROTEIN BROWSER
«
CTCFL-001
CTCFL-003
CTCFL-004
CTCFL-005
CTCFL-006
CTCFL-011
CTCFL-012
CTCFL-013
CTCFL-014
CTCFL-015
CTCFL-016
CTCFL-019
CTCFL-020
CTCFL-021
CTCFL-022
CTCFL-023
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTCFL-001
ENSP00000243914
ENST00000243914
Q8NI51 [Direct mapping]
Transcriptional repressor CTCFL
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0010628 [positive regulation of gene expression]
GO:0016571 [histone methylation]
GO:0042393 [histone binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051569 [regulation of histone H3-K4 methylation]
Show all
 663 aa
75.7 kDa 		No 0
CTCFL-003
ENSP00000360239
ENST00000371196
Q8NI51 [Direct mapping]
Transcriptional repressor CTCFL
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0010628 [positive regulation of gene expression]
GO:0016571 [histone methylation]
GO:0042393 [histone binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051569 [regulation of histone H3-K4 methylation]
Show all
 663 aa
75.7 kDa 		No 0
CTCFL-004
ENSP00000476398
ENST00000609232
Q8NI51 [Direct mapping]
Transcriptional repressor CTCFL
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0010628 [positive regulation of gene expression]
GO:0016571 [histone methylation]
GO:0042393 [histone binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051569 [regulation of histone H3-K4 methylation]
Show all
 663 aa
75.7 kDa 		No 0
CTCFL-005
ENSP00000415329
ENST00000429804
Q8NI51 [Direct mapping]
Transcriptional repressor CTCFL
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0010628 [positive regulation of gene expression]
GO:0016571 [histone methylation]
GO:0042393 [histone binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051569 [regulation of histone H3-K4 methylation]
Show all
 613 aa
69.9 kDa 		No 0
CTCFL-006
ENSP00000409344
ENST00000432255
Q8NI51 [Direct mapping]
Transcriptional repressor CTCFL
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0010628 [positive regulation of gene expression]
GO:0016571 [histone methylation]
GO:0042393 [histone binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051569 [regulation of histone H3-K4 methylation]
Show all
 483 aa
54.2 kDa 		No 0
CTCFL-011
ENSP00000477165
ENST00000608158
V9GYX4 [Direct mapping]
Transcriptional repressor CTCFL
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 404 aa
45.8 kDa 		No 0
CTCFL-012
ENSP00000476577
ENST00000481655
V9GYX4 [Direct mapping]
Transcriptional repressor CTCFL
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 404 aa
45.8 kDa 		No 0
CTCFL-013
ENSP00000439998
ENST00000539382
Q8NI51 [Direct mapping]
Transcriptional repressor CTCFL
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0010628 [positive regulation of gene expression]
GO:0016571 [histone methylation]
GO:0042393 [histone binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051569 [regulation of histone H3-K4 methylation]
Show all
 422 aa
48.1 kDa 		No 0
CTCFL-014
ENSP00000476458
ENST00000608425
V9GY73 [Direct mapping]
Transcriptional repressor CTCFL
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 627 aa
71.2 kDa 		No 0
CTCFL-015
ENSP00000476718
ENST00000608903
Q8NI51 [Direct mapping]
Transcriptional repressor CTCFL
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0010628 [positive regulation of gene expression]
GO:0016571 [histone methylation]
GO:0042393 [histone binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051569 [regulation of histone H3-K4 methylation]
Show all
 299 aa
35.4 kDa 		No 0
CTCFL-016
ENSP00000399061
ENST00000422869
Q8NI51 [Direct mapping]
Transcriptional repressor CTCFL
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0010628 [positive regulation of gene expression]
GO:0016571 [histone methylation]
GO:0042393 [histone binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051569 [regulation of histone H3-K4 methylation]
Show all
 573 aa
66 kDa 		No 0
CTCFL-019
ENSP00000476783
ENST00000608263
Q8NI51 [Direct mapping]
Transcriptional repressor CTCFL
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0010628 [positive regulation of gene expression]
GO:0016571 [histone methylation]
GO:0042393 [histone binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051569 [regulation of histone H3-K4 methylation]
Show all
 663 aa
75.7 kDa 		No 0
CTCFL-020
ENSP00000415579
ENST00000423479
Q8NI51 [Direct mapping]
Transcriptional repressor CTCFL
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0010628 [positive regulation of gene expression]
GO:0016571 [histone methylation]
GO:0042393 [histone binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051569 [regulation of histone H3-K4 methylation]
Show all
 700 aa
80 kDa 		No 0
CTCFL-021
ENSP00000392034
ENST00000433949
Q8NI51 [Direct mapping]
Transcriptional repressor CTCFL
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0010628 [positive regulation of gene expression]
GO:0016571 [histone methylation]
GO:0042393 [histone binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051569 [regulation of histone H3-K4 methylation]
Show all
 460 aa
52.7 kDa 		No 1
CTCFL-022
ENSP00000437999
ENST00000502686
Q8NI51 [Direct mapping]
Transcriptional repressor CTCFL
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0010628 [positive regulation of gene expression]
GO:0016571 [histone methylation]
GO:0042393 [histone binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051569 [regulation of histone H3-K4 methylation]
Show all
 403 aa
46.5 kDa 		No 1
CTCFL-023
ENSP00000477488
ENST00000608440
Q8NI51 [Direct mapping]
Transcriptional repressor CTCFL
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0010628 [positive regulation of gene expression]
GO:0016571 [histone methylation]
GO:0042393 [histone binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051569 [regulation of histone H3-K4 methylation]
Show all
 665 aa
75.8 kDa 		No 1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.