Cell atlas - SNX21 - The Human Protein Atlas

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SNX21

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubule organizing center
	Vesicles

Human cell
	Centrosome
	Vesicles

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GENERAL INFORMATION
Gene name	SNX21
Gene description	Sorting nexin family member 21
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubule organizing center & vesicles.
RNA cell category	Cell line enhanced (PC-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved), Microtubule organizing center (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA046359
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (PC-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubule organizing center & vesicles.

Main location

Vesicles (approved), Microtubule organizing center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046359	PC-3	No staining
	HPA046359	SiHa	Vesicles
	HPA046359	U-2 OS	Vesicles
	HPA046359	U-2 OS	Microtubule organizing center

GENE INFORMATION
Gene name	SNX21 (HGNC Symbol)
Synonyms	C20orf161, dJ337O18.4, SNX-L
Description	Sorting nexin family member 21 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. The specific function of this protein has not been determined. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	45833810 - 45843275
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124104 (version 83.38)
Entrez gene	90203
UniProt	Q969T3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q969T3
Antibodypedia	SNX21 antibodies

PROTEIN BROWSER

SNX21-003	SNX21-005	SNX21-006	SNX21-010	SNX21-011	SNX21-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SNX21-003 ENSP00000361620 ENST00000372542	Q5JZH3 [Direct mapping] Sorting nexin-21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0035091 [phosphatidylinositol binding] Show all	364 aa 40.4 kDa	No	0
SNX21-005 ENSP00000420169 ENST00000462307	Q969T3 [Direct mapping] Sorting nexin-21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0015031 [protein transport] GO:0030659 [cytoplasmic vesicle membrane] GO:0031901 [early endosome membrane] GO:0032266 [phosphatidylinositol-3-phosphate binding] Show all	158 aa 17 kDa	No	0
SNX21-006 ENSP00000361619 ENST00000372541	Q5JZH4 [Direct mapping] Sorting nexin-21; cDNA FLJ55851, highly similar to Sorting nexin-21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		149 aa 16.1 kDa	No	0
SNX21-010 ENSP00000418593 ENST00000491381	Q969T3 [Direct mapping] Sorting nexin-21 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0015031 [protein transport] GO:0030659 [cytoplasmic vesicle membrane] GO:0031901 [early endosome membrane] GO:0032266 [phosphatidylinositol-3-phosphate binding] GO:0035091 [phosphatidylinositol binding] Show all	373 aa 41.4 kDa	No	0
SNX21-011 ENSP00000344586 ENST00000342644	Q969T3 [Direct mapping] Sorting nexin-21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0015031 [protein transport] GO:0030659 [cytoplasmic vesicle membrane] GO:0031901 [early endosome membrane] GO:0032266 [phosphatidylinositol-3-phosphate binding] GO:0035091 [phosphatidylinositol binding] Show all	199 aa 21.8 kDa	No	0
SNX21-201 ENSP00000478395 ENST00000614929	Q05DJ0 [Direct mapping] SNX21 protein; Sorting nexin-21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		165 aa 17.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.