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The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000790 [nuclear chromatin] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001135 [transcription factor activity, RNA polymerase II transcription factor recruiting] GO:0003682 [chromatin binding] GO:0003713 [transcription coactivator activity] GO:0004402 [histone acetyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0010628 [positive regulation of gene expression] GO:0016573 [histone acetylation] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030521 [androgen receptor signaling pathway] GO:0032870 [cellular response to hormone stimulus] GO:0035257 [nuclear hormone receptor binding] GO:0035264 [multicellular organism growth] GO:0035624 [receptor transactivation] GO:0045618 [positive regulation of keratinocyte differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046966 [thyroid hormone receptor binding] GO:0046983 [protein dimerization activity] GO:0047485 [protein N-terminus binding] GO:0048589 [developmental growth] GO:0050681 [androgen receptor binding] GO:0060068 [vagina development] GO:0060713 [labyrinthine layer morphogenesis] GO:0060744 [mammary gland branching involved in thelarche] GO:0070062 [extracellular exosome] GO:0071392 [cellular response to estradiol stimulus] GO:0072091 [regulation of stem cell proliferation] GO:0090575 [RNA polymerase II transcription factor complex] GO:2000035 [regulation of stem cell division] GO:2000036 [regulation of stem cell population maintenance] GO:2000737 [negative regulation of stem cell differentiation] GO:2001141 [regulation of RNA biosynthetic process]
