Tissue expression of MATN4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MATN4
Gene description	Matrilin 4
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (pancreas, skin, breast)
GTEx:	Group enriched (pancreas, skin, testis, cervix, uterine, vagina, salivary gland)
FANTOM5:	Group enriched (seminal vesicle, pancreas)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pancreas, skin, breast)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (pancreas, skin, testis, cervix, uterine, vagina, salivary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (seminal vesicle, pancreas)

GENE INFORMATION
Gene name	MATN4
Synonyms
Description	Matrilin 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of von Willebrand factor A domain-containing protein family. The proteins of this family are thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This family member is thought to be play a role in reorganizing and regenerating the corneal matrix in granular and lattice type I dystrophies. It may also be involved in wound healing in the dentin-pulp complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	45293445 - 45308529
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124159 (version 83.38)
Entrez gene	8785
UniProt	O95460 (UniProt - Evidence at protein level)
neXtProt	NX_O95460
Antibodypedia	MATN4 antibodies

PROTEIN BROWSER

MATN4-001	MATN4-002	MATN4-004	MATN4-201	MATN4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MATN4-001 ENSP00000361842 ENST00000372756	O95460 [Direct mapping] Matrilin-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0030198 [extracellular matrix organization] GO:0048678 [response to axon injury] Show all	581 aa 64.1 kDa	Yes	0
MATN4-002 ENSP00000361840 ENST00000372754	O95460 [Direct mapping] Matrilin-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0030198 [extracellular matrix organization] Show all	622 aa 68.5 kDa	Yes	0
MATN4-004 ENSP00000353819 ENST00000360607	O95460 [Direct mapping] Matrilin-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0030198 [extracellular matrix organization] Show all	540 aa 59.6 kDa	Yes	0
MATN4-201 ENSP00000243983 ENST00000353917	A6NNA4 [Direct mapping] Matrilin-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		499 aa 55.1 kDa	Yes	0
MATN4-202 ENSP00000440328 ENST00000537548	O95460 [Direct mapping] Matrilin-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0030198 [extracellular matrix organization] Show all	581 aa 64.1 kDa	Yes	0