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NCOA5

CANCER ATLAS

Gene description

 Nuclear receptor coactivator 5

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA050231

GENE INFORMATION

Gene name

 NCOA5 (HGNC Symbol)

Synonyms

 bA465L10.6, CIA

Description

 Nuclear receptor coactivator 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.12

Chromosome location (bp)

 46060985 - 46089952

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124160 (version 83.38)

Entrez gene

 57727

UniProt

 Q9HCD5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HCD5

Antibodypedia

 NCOA5 antibodies

PROTEIN BROWSER
NCOA5-001
NCOA5-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NCOA5-001
ENSP00000290231
ENST00000290231
Q9HCD5 [Direct mapping]
Nuclear receptor coactivator 5
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0015629 [actin cytoskeleton]
GO:0042593 [glucose homeostasis]
GO:0044822 [poly(A) RNA binding]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
Show all
 579 aa
65.5 kDa 		No 0
NCOA5-002
ENSP00000361365
ENST00000372291
Q5JY17 [Direct mapping]
Nuclear receptor coactivator 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 104 aa
13.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.