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Cancer cells generally showed strong cytoplasmic and membranous immunoreactivity.
GENE INFORMATION
Gene name
VAPB (HGNC Symbol)
Synonyms
ALS8, VAP-B, VAP-C
Description
VAMP (vesicle-associated membrane protein)-associated protein B and C (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]
O95292 [Direct mapping] Vesicle-associated membrane protein-associated protein B/C Q53XM7 [Target identity:100%; Query identity:100%] VAMP (Vesicle-associated membrane protein)-associated protein B and C; VAMP (Vesicle-associated membrane protein)-associated protein B and C, isoform CRA_b; cDNA FLJ13179 fis, clone NT2RP3003918, highly similar to Vesicle-associated membrane protein-associated protein B/C
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Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006665 [sphingolipid metabolic process] GO:0006874 [cellular calcium ion homeostasis] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006987 [activation of signaling protein activity involved in unfolded protein response] GO:0007029 [endoplasmic reticulum organization] GO:0008017 [microtubule binding] GO:0016021 [integral component of membrane] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019899 [enzyme binding] GO:0030148 [sphingolipid biosynthetic process] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0033149 [FFAT motif binding] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0044790 [negative regulation by host of viral release from host cell] GO:0044791 [positive regulation by host of viral release from host cell] GO:0044828 [negative regulation by host of viral genome replication] GO:0044829 [positive regulation by host of viral genome replication] GO:0045070 [positive regulation of viral genome replication] GO:0046725 [negative regulation by virus of viral protein levels in host cell] GO:0046982 [protein heterodimerization activity] GO:0048487 [beta-tubulin binding] GO:0090114 [COPII-coated vesicle budding]
O95292 [Direct mapping] Vesicle-associated membrane protein-associated protein B/C
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Transporters Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006665 [sphingolipid metabolic process] GO:0006874 [cellular calcium ion homeostasis] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006987 [activation of signaling protein activity involved in unfolded protein response] GO:0007029 [endoplasmic reticulum organization] GO:0008017 [microtubule binding] GO:0016021 [integral component of membrane] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019899 [enzyme binding] GO:0030148 [sphingolipid biosynthetic process] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0033149 [FFAT motif binding] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0044790 [negative regulation by host of viral release from host cell] GO:0044791 [positive regulation by host of viral release from host cell] GO:0044828 [negative regulation by host of viral genome replication] GO:0044829 [positive regulation by host of viral genome replication] GO:0045070 [positive regulation of viral genome replication] GO:0046725 [negative regulation by virus of viral protein levels in host cell] GO:0046982 [protein heterodimerization activity] GO:0048487 [beta-tubulin binding] GO:0090114 [COPII-coated vesicle budding]
