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ATP5E

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GENERAL INFORMATION

Gene name

 ATP5E

Gene description

 ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 ATP5E

Synonyms

Description

 ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the epsilon subunit of the catalytic core. Two pseudogenes of this gene are located on chromosomes 4 and 13. Read-through transcripts that include exons from this gene are expressed from the upstream gene SLMO2.[provided by RefSeq, Mar 2011]

Chromosome

 20

Cytoband

 q13.32

Chromosome location (bp)

 59025467 - 59032382

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124172 (version 83.38)

Entrez gene

 514

UniProt

 P56381 (UniProt - Evidence at protein level)

neXtProt

 NX_P56381

Antibodypedia

 ATP5E antibodies

PROTEIN BROWSER
ATP5E-001
ATP5E-002
ATP5E-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP5E-001
ENSP00000243997
ENST00000243997
P56381 [Direct mapping]
ATP synthase subunit epsilon, mitochondrial
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000275 [mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0005759 [mitochondrial matrix]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0016887 [ATPase activity]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
Show all
 51 aa
5.8 kDa 		No 0
ATP5E-002
ENSP00000379019
ENST00000395659
P56381 [Direct mapping]
ATP synthase subunit epsilon, mitochondrial
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0000275 [mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0005759 [mitochondrial matrix]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0016887 [ATPase activity]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
Show all
 51 aa
5.8 kDa 		No 0
ATP5E-003
ENSP00000379023
ENST00000395663
P56381 [Direct mapping]
ATP synthase subunit epsilon, mitochondrial
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0000275 [mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0005759 [mitochondrial matrix]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0016887 [ATPase activity]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
Show all
 51 aa
5.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.