Expression of GDAP1L1 in cancer - Summary

CANCER ATLAS

Gene description

Ganglioside induced differentiation associated protein 1-like 1

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA063265

GENE INFORMATION
Gene name	GDAP1L1
Synonyms
Description	Ganglioside induced differentiation associated protein 1-like 1 (HGNC Symbol)
Entrez gene summary	The ganglioside GD3 synthase causes cell differentiation with neurite sprouting when transfected into the mouse neuroblastoma cell line Neuro2a. After differentiation, the expression of several genes is upregulated, including one that encodes a protein termed ganglioside-induced differentiation-associated protein 1 (Gdap1). A similar gene was found in humans, and mutations in the human gene are associated with Charcot-Marie-Tooth type 4A disease. The protein encoded by this gene is similar in sequence to the human GDAP1 protein. Several transcript variants encoding different isoforms, as well as a noncoding transcript variant, have been found for this gene. [provided by RefSeq, Feb 2012]
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	44247099 - 44280917
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124194 (version 83.38)
Entrez gene	78997
UniProt	Q96MZ0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96MZ0
Antibodypedia	GDAP1L1 antibodies

PROTEIN BROWSER

GDAP1L1-001	GDAP1L1-002	GDAP1L1-004	GDAP1L1-005	GDAP1L1-006	GDAP1L1-201	GDAP1L1-202	GDAP1L1-203	GDAP1L1-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GDAP1L1-001 ENSP00000341782 ENST00000342560	Q96MZ0 [Direct mapping] Ganglioside-induced differentiation-associated protein 1-like 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006749 [glutathione metabolic process] Show all	367 aa 42 kDa	No	2
GDAP1L1-002 ENSP00000391714 ENST00000447658	Q5TE58 [Direct mapping] Ganglioside-induced differentiation-associated protein 1-like 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005737 [cytoplasm] GO:0006749 [glutathione metabolic process] Show all	123 aa 14.2 kDa	No	0
GDAP1L1-004 ENSP00000392881 ENST00000438466	Q5TE61 [Direct mapping] Ganglioside-induced differentiation-associated protein 1-like 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006749 [glutathione metabolic process] Show all	288 aa 32.9 kDa	No	0
GDAP1L1-005 ENSP00000362043 ENST00000372952	Q96MZ0 [Direct mapping] Ganglioside-induced differentiation-associated protein 1-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006749 [glutathione metabolic process] Show all	147 aa 16.5 kDa	No	0
GDAP1L1-006 ENSP00000404128 ENST00000445952	H0Y6A7 [Direct mapping] Ganglioside-induced differentiation-associated protein 1-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006749 [glutathione metabolic process] Show all	251 aa 28.8 kDa	No	0
GDAP1L1-201 ENSP00000440498 ENST00000537864	Q96MZ0 [Direct mapping] Ganglioside-induced differentiation-associated protein 1-like 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006749 [glutathione metabolic process] Show all	386 aa 43.8 kDa	No	2
GDAP1L1-202 ENSP00000480502 ENST00000612599	A0A087WWT8 [Direct mapping] Ganglioside-induced differentiation-associated protein 1-like 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006749 [glutathione metabolic process] GO:0016021 [integral component of membrane] Show all	296 aa 33.8 kDa	No	2
GDAP1L1-203 ENSP00000483113 ENST00000616372	A0A087X057 [Direct mapping] Ganglioside-induced differentiation-associated protein 1-like 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006749 [glutathione metabolic process] GO:0016021 [integral component of membrane] Show all	364 aa 41.2 kDa	No	2
GDAP1L1-204 ENSP00000478701 ENST00000617075	H0UIB3 [Direct mapping] Ganglioside-induced differentiation-associated protein 1-like 1; Ganglioside-induced differentiation-associated protein 1-like 1, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006749 [glutathione metabolic process] GO:0016021 [integral component of membrane] Show all	278 aa 32 kDa	No	2