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Moderate cytoplasmic positivity was observed in most malignant cells. Several cases of colorectal cancers as well as a few cases of malignant carcinoids and pancreatic cancers displayed strong cytoplasmic positivity.
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Q9Y6D5 [Direct mapping] Brefeldin A-inhibited guanine nucleotide-exchange protein 2
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MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)