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Several cases of testis cancers displayed moderate to strong nuclear and cytoplasmic positivity. Few cases of squamous cell carcinomas of cervix, skin and lung cancers showed moderate nuclear staining. Remaining cancer tissues were weakly stained or negative.
Several testis cancers along with few colorectal, breast, prostate, skin cancers and gliomas showed moderate nuclear and/or cytoplasmic positivity. Rare cases of seminomas of testis exhibited strong cytoplasmic immunoreactivity. Other cancers were in general weakly stained or negative.
Testis, colorectal, breast, lung, skin, gastric, gynecological cancers and melanomas and lymphomas showed moderate to strong nuclear and cytoplasmic positivity. Renal, pancreatic and liver cancer were mainly negative.
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
