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STAU1

CANCER ATLAS

Gene description

 Staufen double-stranded RNA binding protein 1

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049892
CAB020839

GENE INFORMATION

Gene name

 STAU1 (HGNC Symbol)

Synonyms

 PPP1R150, STAU

Description

 Staufen double-stranded RNA binding protein 1 (HGNC Symbol)

Entrez gene summary

 Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.13

Chromosome location (bp)

 49113339 - 49188367

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124214 (version 83.38)

Entrez gene

 6780

UniProt

 O95793 (UniProt - Evidence at protein level)

neXtProt

 NX_O95793

Antibodypedia

 STAU1 antibodies

PROTEIN BROWSER
STAU1-001
STAU1-002
STAU1-003
STAU1-004
STAU1-005
STAU1-006
STAU1-007
STAU1-008
STAU1-201
STAU1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STAU1-001
ENSP00000360922
ENST00000371856
O95793 [Direct mapping]
Double-stranded RNA-binding protein Staufen homolog 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005791 [rough endoplasmic reticulum]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0008157 [protein phosphatase 1 binding]
GO:0008298 [intracellular mRNA localization]
GO:0010494 [cytoplasmic stress granule]
GO:0016020 [membrane]
GO:0030425 [dendrite]
GO:0030529 [ribonucleoprotein complex]
GO:0034599 [cellular response to oxidative stress]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0044297 [cell body]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0046726 [positive regulation by virus of viral protein levels in host cell]
GO:0070062 [extracellular exosome]
GO:1900273 [positive regulation of long-term synaptic potentiation]
Show all
 577 aa
63.2 kDa 		No 0
STAU1-002
ENSP00000353604
ENST00000360426
O95793 [Direct mapping]
Double-stranded RNA-binding protein Staufen homolog 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005791 [rough endoplasmic reticulum]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0010494 [cytoplasmic stress granule]
GO:0016020 [membrane]
GO:0030425 [dendrite]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0044297 [cell body]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0046726 [positive regulation by virus of viral protein levels in host cell]
GO:0070062 [extracellular exosome]
Show all
 496 aa
54.9 kDa 		No 0
STAU1-003
ENSP00000323443
ENST00000347458
O95793 [Direct mapping]
Double-stranded RNA-binding protein Staufen homolog 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005791 [rough endoplasmic reticulum]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0010494 [cytoplasmic stress granule]
GO:0016020 [membrane]
GO:0030425 [dendrite]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0044297 [cell body]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0046726 [positive regulation by virus of viral protein levels in host cell]
GO:0070062 [extracellular exosome]
Show all
 496 aa
54.9 kDa 		No 0
STAU1-004
ENSP00000345425
ENST00000340954
O95793 [Direct mapping]
Double-stranded RNA-binding protein Staufen homolog 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005791 [rough endoplasmic reticulum]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0010494 [cytoplasmic stress granule]
GO:0016020 [membrane]
GO:0030425 [dendrite]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0044297 [cell body]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0046726 [positive regulation by virus of viral protein levels in host cell]
GO:0070062 [extracellular exosome]
Show all
 496 aa
54.9 kDa 		No 0
STAU1-005
ENSP00000416779
ENST00000437404
Q5JW28 [Direct mapping]
Double-stranded RNA-binding protein Staufen homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 199 aa
22.5 kDa 		No 0
STAU1-006
ENSP00000360867
ENST00000371802
O95793 [Direct mapping]
Double-stranded RNA-binding protein Staufen homolog 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005791 [rough endoplasmic reticulum]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0010494 [cytoplasmic stress granule]
GO:0016020 [membrane]
GO:0030425 [dendrite]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0044297 [cell body]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0046726 [positive regulation by virus of viral protein levels in host cell]
GO:0070062 [extracellular exosome]
Show all
 502 aa
55.6 kDa 		No 0
STAU1-007
ENSP00000360857
ENST00000371792
Q5JW30 [Direct mapping]
Double-stranded RNA-binding protein Staufen homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 494 aa
54.7 kDa 		No 0
STAU1-008
ENSP00000398785
ENST00000456866
F6UDC6 [Direct mapping]
Double-stranded RNA-binding protein Staufen homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 129 aa
14.7 kDa 		No 0
STAU1-201
ENSP00000360893
ENST00000371828
O95793 [Direct mapping]
Double-stranded RNA-binding protein Staufen homolog 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005791 [rough endoplasmic reticulum]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0010494 [cytoplasmic stress granule]
GO:0016020 [membrane]
GO:0030425 [dendrite]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0044297 [cell body]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0046726 [positive regulation by virus of viral protein levels in host cell]
GO:0070062 [extracellular exosome]
Show all
 502 aa
55.6 kDa 		No 0
STAU1-202
ENSP00000484011
ENST00000614381
A0A087X1A5 [Direct mapping]
Double-stranded RNA-binding protein Staufen homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 493 aa
54.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.