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Most squamous cell carcinomas of cervix displayed moderate cytoplasmic staining which also was observed in occasional cases of urothelial and pancreatic cancers. Remaining malignancies were generally negative.
GENE INFORMATION
Gene name
CDH26 (HGNC Symbol)
Synonyms
VR20
Description
Cadherin 26 (HGNC Symbol)
Entrez gene summary
Cadherins are a family of adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in all solid tissues and modulate a wide variety of processes, including cell polarization and migration. Cadherin domains occur as repeats in the extracellular region and are thought to contribute to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. This gene encodes a cadherin domain-containing protein whose specific function has not yet been determined. Alternative splicing occurs at this locus and two transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jul 2008]
