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Most malignant cells showed strong nuclear positivity. Additional weaker cytoplasmic staining was observed in a majority of cases. Most hepatocellular carcinomas and several renal cancers were negative.
GENE INFORMATION
Gene name
SNAI1 (HGNC Symbol)
Synonyms
SLUGH2, SNA, SNAH, SNAIL, SNAIL1
Description
Snail family zinc finger 1 (HGNC Symbol)
Entrez gene summary
The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]