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Majority of cancers displayed moderate to strong cytoplasmic with additional membranous positivity in several cases. Lymphoma was weakly stained or negative.
GENE INFORMATION
Gene name
FASTKD3 (HGNC Symbol)
Synonyms
FLJ23274, MGC5297
Description
FAST kinase domains 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of a small family of Fas-activated serine/threonine kinase domain (FASTKD) containing proteins that share an amino terminal mitochondrial targeting domain and multiple carboxy terminal FAST domains as well as a putative RNA-binding RAP domain. The members of this family are ubiquitously expressed and are generally most abundant in mitochondria-enriched tissues such as heart, skeletal muscle and brown-adipose tissue. Some members of this protein family may play a role in apoptosis. The protein encoded by this gene interacts with components of the mitochondrial respiratory and translation networks. A pseudogene of this gene is also present on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
