Cell atlas - PEPD - The Human Protein Atlas

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PEPD

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PEPD
Gene description	Peptidase D
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA015599
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA015599	A549	Nucleoplasm
	HPA015599	RT4	Nucleoplasm

GENE INFORMATION
Gene name	PEPD
Synonyms
Description	Peptidase D (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Chromosome	19
Cytoband	q13.11
Chromosome location (bp)	33386950 - 33521794
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124299 (version 83.38)
Entrez gene	5184
UniProt	P12955 (UniProt - Evidence at protein level)
neXtProt	NX_P12955
Antibodypedia	PEPD antibodies

PROTEIN BROWSER

PEPD-001	PEPD-002	PEPD-003	PEPD-009	PEPD-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PEPD-001 ENSP00000244137 ENST00000244137	P12955 [Direct mapping] Xaa-Pro dipeptidase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0006520 [cellular amino acid metabolic process] GO:0008233 [peptidase activity] GO:0016805 [dipeptidase activity] GO:0030145 [manganese ion binding] GO:0030574 [collagen catabolic process] GO:0070062 [extracellular exosome] Show all	493 aa 54.5 kDa	No	0
PEPD-002 ENSP00000380226 ENST00000397032	P12955 [Direct mapping] Xaa-Pro dipeptidase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0006520 [cellular amino acid metabolic process] GO:0016805 [dipeptidase activity] GO:0030145 [manganese ion binding] GO:0030574 [collagen catabolic process] GO:0070062 [extracellular exosome] Show all	452 aa 49.7 kDa	No	0
PEPD-003 ENSP00000391890 ENST00000436370	P12955 [Direct mapping] Xaa-Pro dipeptidase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0006520 [cellular amino acid metabolic process] GO:0016805 [dipeptidase activity] GO:0030145 [manganese ion binding] GO:0030574 [collagen catabolic process] GO:0070062 [extracellular exosome] Show all	429 aa 47.3 kDa	No	0
PEPD-009 ENSP00000468516 ENST00000588328	K7ES25 [Direct mapping] Xaa-Pro dipeptidase Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	194 aa 21.6 kDa	No	0
PEPD-014 ENSP00000476514 ENST00000609145	V9GY89 [Direct mapping] Xaa-Pro dipeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	104 aa 11.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.