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STAMBP

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GENERAL INFORMATION

Gene name

 STAMBP

Gene description

 STAM binding protein

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & cytosol.

RNA cell category

 Cell line enriched (LHCN-M2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Additional location

 In addition localized to the Plasma membrane (approved), Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA035800
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (LHCN-M2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & cytosol.

Main location

 Nucleoplasm (supported)

Additional location

 Plasma membrane (approved), Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA035800 A-431 Nucleoplasm
HPA035800 U-2 OS Nucleoplasm
Plasma membrane
HPA035800 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 STAMBP (HGNC Symbol)

Synonyms

 AMSH

Description

 STAM binding protein (HGNC Symbol)

Entrez gene summary

 Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p13.1

Chromosome location (bp)

 73828916 - 73873659

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124356 (version 83.38)

Entrez gene

 10617

UniProt

 O95630 (UniProt - Evidence at protein level)

neXtProt

 NX_O95630

Antibodypedia

 STAMBP antibodies

PROTEIN BROWSER
STAMBP-001
STAMBP-002
STAMBP-003
STAMBP-004
STAMBP-005
STAMBP-012
STAMBP-201
STAMBP-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STAMBP-001
ENSP00000377633
ENST00000394070
O95630 [Direct mapping]
STAM-binding protein
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0007259 [JAK-STAT cascade]
GO:0008237 [metallopeptidase activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling]
GO:0016579 [protein deubiquitination]
GO:0019904 [protein domain specific binding]
GO:0032154 [cleavage furrow]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 424 aa
48.1 kDa 		No 0
STAMBP-002
ENSP00000386548
ENST00000409707
O95630 [Direct mapping]
STAM-binding protein
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0007259 [JAK-STAT cascade]
GO:0008237 [metallopeptidase activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling]
GO:0016579 [protein deubiquitination]
GO:0019904 [protein domain specific binding]
GO:0032154 [cleavage furrow]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 424 aa
48.1 kDa 		No 0
STAMBP-003
ENSP00000413874
ENST00000432295
C9JK83 [Direct mapping]
STAM-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
Show all
 318 aa
36.2 kDa 		No 0
STAMBP-004
ENSP00000413291
ENST00000452725
C9JZ93 [Direct mapping]
STAM-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 137 aa
16 kDa 		No 0
STAMBP-005
ENSP00000390921
ENST00000424659
C9JEK5 [Direct mapping]
STAM-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 163 aa
19.3 kDa 		No 0
STAMBP-012
ENSP00000443502
ENST00000536064
F5H5B9 [Direct mapping]
STAM-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 209 aa
24.6 kDa 		No 0
STAMBP-201
ENSP00000344742
ENST00000339566
O95630 [Direct mapping]
STAM-binding protein
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0007259 [JAK-STAT cascade]
GO:0008237 [metallopeptidase activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling]
GO:0016579 [protein deubiquitination]
GO:0019904 [protein domain specific binding]
GO:0032154 [cleavage furrow]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 424 aa
48.1 kDa 		No 0
STAMBP-202
ENSP00000377636
ENST00000394073
O95630 [Direct mapping]
STAM-binding protein
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0007259 [JAK-STAT cascade]
GO:0008237 [metallopeptidase activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling]
GO:0016579 [protein deubiquitination]
GO:0019904 [protein domain specific binding]
GO:0032154 [cleavage furrow]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 424 aa
48.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.