Expression of PAIP2B in cancer - Summary

CANCER ATLAS

Gene description

Poly(A) binding protein interacting protein 2B

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA046784

GENE INFORMATION
Gene name	PAIP2B (HGNC Symbol)
Synonyms	KIAA1155
Description	Poly(A) binding protein interacting protein 2B (HGNC Symbol)
Entrez gene summary	Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]
Chromosome	2
Cytoband	p13.3
Chromosome location (bp)	71182739 - 71227083
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124374 (version 83.38)
Entrez gene	400961
UniProt	Q9ULR5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULR5
Antibodypedia	PAIP2B antibodies

PROTEIN BROWSER

PAIP2B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAIP2B-001 ENSP00000244221 ENST00000244221	Q9ULR5 [Direct mapping] Polyadenylate-binding protein-interacting protein 2B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000900 [translation repressor activity, nucleic acid binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0045947 [negative regulation of translational initiation] Show all	123 aa 14.2 kDa	No	0