Expression of MPHOSPH10 in cancer - Summary

CANCER ATLAS

Gene description

M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035059	HPA035060

GENE INFORMATION
Gene name	MPHOSPH10 (HGNC Symbol)
Synonyms	CT90, MPP10, MPP10P, PPP1R106
Description	M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. [provided by RefSeq, Dec 2010]
Chromosome	2
Cytoband	p13.3
Chromosome location (bp)	71130314 - 71150101
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124383 (version 83.38)
Entrez gene	10199
UniProt	O00566 (UniProt - Evidence at protein level)
neXtProt	NX_O00566
Antibodypedia	MPHOSPH10 antibodies

PROTEIN BROWSER

MPHOSPH10-001	MPHOSPH10-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPHOSPH10-001 ENSP00000244230 ENST00000244230	O00566 [Direct mapping] U3 small nucleolar ribonucleoprotein protein MPP10 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000375 [RNA splicing, via transesterification reactions] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005694 [chromosome] GO:0005730 [nucleolus] GO:0005732 [small nucleolar ribonucleoprotein complex] GO:0006364 [rRNA processing] GO:0006396 [RNA processing] GO:0008380 [RNA splicing] GO:0010923 [negative regulation of phosphatase activity] GO:0032040 [small-subunit processome] GO:0034457 [Mpp10 complex] GO:0044822 [poly(A) RNA binding] Show all	681 aa 78.9 kDa	No	0
MPHOSPH10-002 ENSP00000475545 ENST00000498451	U3KQ48 [Direct mapping] U3 small nucleolar ribonucleoprotein protein MPP10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005732 [small nucleolar ribonucleoprotein complex] GO:0006364 [rRNA processing] GO:0032040 [small-subunit processome] GO:0034457 [Mpp10 complex] Show all	462 aa 53.6 kDa	No	1