Expression of ATP8A1 in cancer - Summary

CANCER ATLAS

Gene description

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA049948	HPA052935

GENE INFORMATION
Gene name	ATP8A1 (HGNC Symbol)
Synonyms	ATPIA
Description	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 (HGNC Symbol)
Entrez gene summary	The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	p13
Chromosome location (bp)	42408373 - 42657105
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124406 (version 83.38)
Entrez gene	10396
UniProt	Q9Y2Q0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2Q0
Antibodypedia	ATP8A1 antibodies

PROTEIN BROWSER

ATP8A1-001	ATP8A1-002	ATP8A1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP8A1-001 ENSP00000371084 ENST00000381668	Q9Y2Q0 [Direct mapping] Phospholipid-transporting ATPase IA Show all	Enzymes ENZYME proteins Hydrolases Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007612 [learning] GO:0008152 [metabolic process] GO:0015914 [phospholipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019829 [cation-transporting ATPase activity] GO:0030335 [positive regulation of cell migration] GO:0034220 [ion transmembrane transport] GO:0042584 [chromaffin granule membrane] GO:0045332 [phospholipid translocation] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0061092 [positive regulation of phospholipid translocation] GO:0070062 [extracellular exosome] GO:0098655 [cation transmembrane transport] Show all	1164 aa 131.4 kDa	No	>9
ATP8A1-002 ENSP00000426636 ENST00000510289	Q4G1C1 [Direct mapping] ATP8A1 protein; Phospholipid-transporting ATPase IA Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] Show all	55 aa 6.5 kDa	No	0
ATP8A1-003 ENSP00000264449 ENST00000264449	Q9Y2Q0 [Direct mapping] Phospholipid-transporting ATPase IA Show all	Enzymes ENZYME proteins Hydrolases Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0015914 [phospholipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019829 [cation-transporting ATPase activity] GO:0034220 [ion transmembrane transport] GO:0042584 [chromaffin granule membrane] GO:0045332 [phospholipid translocation] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098655 [cation transmembrane transport] Show all	1149 aa 129.7 kDa	No	>9