Tissue expression of CEACAM8 - Summary - The Human Protein Atlas

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CEACAM8

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CEACAM8
Gene description	Carcinoembryonic antigen-related cell adhesion molecule 8
Protein class	CD markers Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (bone marrow)
GTEx:	Group enriched (spleen, lung)
FANTOM5:	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in bone marrow.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. CAB033676
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (bone marrow)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (spleen, lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION
Gene name	CEACAM8 (HGNC Symbol)
Synonyms	CD66b, CGM6
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	42580241 - 42740384
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124469 (version 83.38)
Entrez gene	1088
UniProt	P31997 (UniProt - Evidence at protein level)
neXtProt	NX_P31997
Antibodypedia	CEACAM8 antibodies

PROTEIN BROWSER

CEACAM8-001	CEACAM8-002	CEACAM8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEACAM8-001 ENSP00000244336 ENST00000244336	P31997 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 8 Q0Z7S6 [Target identity:100%; Query identity:100%] Carcinoembryonic antigen-related cell adhesion molecule 8; cDNA, FLJ93041, Homo sapiens carcinoembryonic antigen-related cell adhesionmolecule 8 (CEACAM8), mRNA Show all	CD markers MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007596 [blood coagulation] GO:0031225 [anchored component of membrane] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	349 aa 38.2 kDa	Yes	0
CEACAM8-002 ENSP00000472166 ENST00000599005	M0R1X3 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 8 Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		51 aa 5.3 kDa	No	0
CEACAM8-201 ENSP00000484915 ENST00000614151	A0A087X2E2 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 8 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	344 aa 37.5 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.