Expression of GRM4 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Glutamate receptor, metabotropic 4

Protein class

G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

CAB022096

GENE INFORMATION
Gene name	GRM4 (HGNC Symbol)
Synonyms	GPRC1D, mGlu4, MGLUR4
Description	Glutamate receptor, metabotropic 4 (HGNC Symbol)
Entrez gene summary	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Chromosome	6
Cytoband	p21.31
Chromosome location (bp)	34018645 - 34155622
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124493 (version 83.38)
Entrez gene	2914
UniProt	Q14833 (UniProt - Evidence at transcript level)
neXtProt	NX_Q14833
Antibodypedia	GRM4 antibodies

PROTEIN BROWSER

GRM4-001	GRM4-002	GRM4-003	GRM4-004	GRM4-005	GRM4-011	GRM4-201	GRM4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRM4-001 ENSP00000440556 ENST00000538487	Q14833 [Direct mapping] Metabotropic glutamate receptor 4 A1L4F9 [Target identity:100%; Query identity:100%] Glutamate metabotropic receptor 4; Glutamate receptor, metabotropic 4; Glutamate receptor, metabotropic 4, isoform CRA_a Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001642 [group III metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0007612 [learning] GO:0008066 [glutamate receptor activity] GO:0016021 [integral component of membrane] GO:0031410 [cytoplasmic vesicle] GO:0042734 [presynaptic membrane] GO:0043410 [positive regulation of MAPK cascade] GO:0043523 [regulation of neuron apoptotic process] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	912 aa 101.9 kDa	Yes	7
GRM4-002 ENSP00000363292 ENST00000374177	Q14833 [Direct mapping] Metabotropic glutamate receptor 4 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001642 [group III metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0008066 [glutamate receptor activity] GO:0016021 [integral component of membrane] GO:0031410 [cytoplasmic vesicle] GO:0042734 [presynaptic membrane] GO:0043410 [positive regulation of MAPK cascade] GO:0043523 [regulation of neuron apoptotic process] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	796 aa 88.5 kDa	No	7
GRM4-003 ENSP00000437730 ENST00000544773	Q14833 [Direct mapping] Metabotropic glutamate receptor 4 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001642 [group III metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0008066 [glutamate receptor activity] GO:0016021 [integral component of membrane] GO:0031410 [cytoplasmic vesicle] GO:0042734 [presynaptic membrane] GO:0043410 [positive regulation of MAPK cascade] GO:0043523 [regulation of neuron apoptotic process] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	743 aa 83.6 kDa	No	7
GRM4-004 ENSP00000477466 ENST00000609222	Q14833 [Direct mapping] Metabotropic glutamate receptor 4 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0000187 [activation of MAPK activity] GO:0001642 [group III metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0008066 [glutamate receptor activity] GO:0016021 [integral component of membrane] GO:0031410 [cytoplasmic vesicle] GO:0042734 [presynaptic membrane] GO:0043410 [positive regulation of MAPK cascade] GO:0043523 [regulation of neuron apoptotic process] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	779 aa 87.4 kDa	No	7
GRM4-005 ENSP00000398456 ENST00000455714	Q14833 [Direct mapping] Metabotropic glutamate receptor 4 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0000187 [activation of MAPK activity] GO:0001642 [group III metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0008066 [glutamate receptor activity] GO:0016021 [integral component of membrane] GO:0031410 [cytoplasmic vesicle] GO:0042734 [presynaptic membrane] GO:0043410 [positive regulation of MAPK cascade] GO:0043523 [regulation of neuron apoptotic process] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	772 aa 86.7 kDa	No	7
GRM4-011 ENSP00000476561 ENST00000609443	V9GYB0 [Direct mapping] Metabotropic glutamate receptor 4 Show all	Predicted intracellular proteins Show all	GO:0001642 [group III metabotropic glutamate receptor activity] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042734 [presynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	96 aa 11.1 kDa	No	0
GRM4-201 ENSP00000363296 ENST00000374181	B7ZLU9 [Direct mapping] Metabotropic glutamate receptor 4; Uncharacterized protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001642 [group III metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042734 [presynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	865 aa 96.1 kDa	Yes	7
GRM4-202 ENSP00000437925 ENST00000535756	Q14833 [Direct mapping] Metabotropic glutamate receptor 4 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001642 [group III metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0008066 [glutamate receptor activity] GO:0016021 [integral component of membrane] GO:0031410 [cytoplasmic vesicle] GO:0042734 [presynaptic membrane] GO:0043410 [positive regulation of MAPK cascade] GO:0043523 [regulation of neuron apoptotic process] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	779 aa 87.4 kDa	No	7