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SIRT5

CANCER ATLAS

Gene description

 Sirtuin 5

Protein class

 FDA approved drug targets, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021798
HPA022002
HPA022992

GENE INFORMATION

Gene name

 SIRT5

Synonyms

Description

 Sirtuin 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Chromosome

 6

Cytoband

 p23

Chromosome location (bp)

 13574529 - 13615158

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124523 (version 83.38)

Entrez gene

 23408

UniProt

 Q9NXA8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NXA8

Antibodypedia

 SIRT5 antibodies

PROTEIN BROWSER
SIRT5-001
SIRT5-002
SIRT5-003
SIRT5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SIRT5-001
ENSP00000368564
ENST00000379262
Q9NXA8 [Direct mapping]
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005758 [mitochondrial intermembrane space]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006342 [chromatin silencing]
GO:0006476 [protein deacetylation]
GO:0008270 [zinc ion binding]
GO:0010566 [regulation of ketone biosynthetic process]
GO:0036046 [protein demalonylation]
GO:0036047 [peptidyl-lysine demalonylation]
GO:0036048 [protein desuccinylation]
GO:0036049 [peptidyl-lysine desuccinylation]
GO:0036054 [protein-malonyllysine demalonylase activity]
GO:0036055 [protein-succinyllysine desuccinylase activity]
GO:0061697 [protein-glutaryllysine deglutarylase activity]
GO:0061698 [protein deglutarylation]
GO:0061699 [peptidyl-lysine deglutarylation]
GO:0070403 [NAD+ binding]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
Show all
 299 aa
32.7 kDa 		No 0
SIRT5-002
ENSP00000476228
ENST00000606117
Q9NXA8 [Direct mapping]
NAD-dependent protein deacylase sirtuin-5, mitochondrial
A0A024R012 [Target identity:100%; Query identity:100%]
Sirtuin (Silent mating type information regulation 2 homolog) 5 (S. cerevisiae), isoform CRA_b
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005758 [mitochondrial intermembrane space]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006342 [chromatin silencing]
GO:0006476 [protein deacetylation]
GO:0008270 [zinc ion binding]
GO:0010566 [regulation of ketone biosynthetic process]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0031667 [response to nutrient levels]
GO:0036046 [protein demalonylation]
GO:0036047 [peptidyl-lysine demalonylation]
GO:0036048 [protein desuccinylation]
GO:0036049 [peptidyl-lysine desuccinylation]
GO:0036054 [protein-malonyllysine demalonylase activity]
GO:0036055 [protein-succinyllysine desuccinylase activity]
GO:0061697 [protein-glutaryllysine deglutarylase activity]
GO:0061698 [protein deglutarylation]
GO:0061699 [peptidyl-lysine deglutarylation]
GO:0070403 [NAD+ binding]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
Show all
 310 aa
33.9 kDa 		No 0
SIRT5-003
ENSP00000352830
ENST00000359782
Q9NXA8 [Direct mapping]
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005758 [mitochondrial intermembrane space]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006342 [chromatin silencing]
GO:0006476 [protein deacetylation]
GO:0008270 [zinc ion binding]
GO:0010566 [regulation of ketone biosynthetic process]
GO:0036046 [protein demalonylation]
GO:0036047 [peptidyl-lysine demalonylation]
GO:0036048 [protein desuccinylation]
GO:0036049 [peptidyl-lysine desuccinylation]
GO:0036054 [protein-malonyllysine demalonylase activity]
GO:0036055 [protein-succinyllysine desuccinylase activity]
GO:0061697 [protein-glutaryllysine deglutarylase activity]
GO:0061698 [protein deglutarylation]
GO:0061699 [peptidyl-lysine deglutarylation]
GO:0070403 [NAD+ binding]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
Show all
 292 aa
32 kDa 		No 0
SIRT5-201
ENSP00000380509
ENST00000397350
Q9NXA8 [Direct mapping]
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005758 [mitochondrial intermembrane space]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006342 [chromatin silencing]
GO:0006476 [protein deacetylation]
GO:0008270 [zinc ion binding]
GO:0010566 [regulation of ketone biosynthetic process]
GO:0036046 [protein demalonylation]
GO:0036047 [peptidyl-lysine demalonylation]
GO:0036048 [protein desuccinylation]
GO:0036049 [peptidyl-lysine desuccinylation]
GO:0036054 [protein-malonyllysine demalonylase activity]
GO:0036055 [protein-succinyllysine desuccinylase activity]
GO:0061697 [protein-glutaryllysine deglutarylase activity]
GO:0061698 [protein deglutarylation]
GO:0061699 [peptidyl-lysine deglutarylation]
GO:0070403 [NAD+ binding]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
Show all
 202 aa
21.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.