Tissue expression of SERPINB6 - Summary - The Human Protein Atlas

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SERPINB6

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SERPINB6
Gene description	Serpin peptidase inhibitor, clade B (ovalbumin), member 6
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA009668 , HPA012736
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SERPINB6 (HGNC Symbol)
Synonyms	CAP, DFNB91, PI6, PTI
Description	Serpin peptidase inhibitor, clade B (ovalbumin), member 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
Chromosome	6
Cytoband	p25.2
Chromosome location (bp)	2948159 - 2972165
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124570 (version 83.38)
Entrez gene	5269
UniProt	P35237 (UniProt - Evidence at protein level)
neXtProt	NX_P35237
Antibodypedia	SERPINB6 antibodies

PROTEIN BROWSER

SERPINB6-001	SERPINB6-002	SERPINB6-003	SERPINB6-004	SERPINB6-005	SERPINB6-006	SERPINB6-201	SERPINB6-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINB6-001 ENSP00000369896 ENST00000380524	P35237 [Direct mapping] Serpin B6 A0A024QZX3 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007605 [sensory perception of sound] GO:0010951 [negative regulation of endopeptidase activity] GO:0043234 [protein complex] GO:0070062 [extracellular exosome] GO:0071470 [cellular response to osmotic stress] Show all	376 aa 42.6 kDa	No	0
SERPINB6-002 ENSP00000369891 ENST00000380520	P35237 [Direct mapping] Serpin B6 A0A024QZX3 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007605 [sensory perception of sound] GO:0010951 [negative regulation of endopeptidase activity] GO:0043234 [protein complex] GO:0070062 [extracellular exosome] GO:0071470 [cellular response to osmotic stress] Show all	376 aa 42.6 kDa	No	0
SERPINB6-003 ENSP00000338358 ENST00000335686	P35237 [Direct mapping] Serpin B6 A0A024QZX3 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007605 [sensory perception of sound] GO:0010951 [negative regulation of endopeptidase activity] GO:0043234 [protein complex] GO:0070062 [extracellular exosome] GO:0071470 [cellular response to osmotic stress] Show all	376 aa 42.6 kDa	No	0
SERPINB6-004 ENSP00000369901 ENST00000380529	P35237 [Direct mapping] Serpin B6 A0A024QZX3 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007605 [sensory perception of sound] GO:0010951 [negative regulation of endopeptidase activity] GO:0043234 [protein complex] GO:0070062 [extracellular exosome] GO:0071470 [cellular response to osmotic stress] Show all	376 aa 42.6 kDa	No	0
SERPINB6-005 ENSP00000369912 ENST00000380539	P35237 [Direct mapping] Serpin B6 A0A024QZX3 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007605 [sensory perception of sound] GO:0010951 [negative regulation of endopeptidase activity] GO:0043234 [protein complex] GO:0070062 [extracellular exosome] GO:0071470 [cellular response to osmotic stress] Show all	376 aa 42.6 kDa	No	0
SERPINB6-006 ENSP00000369919 ENST00000380546	P35237 [Direct mapping] Serpin B6 A0A024QZX3 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007605 [sensory perception of sound] GO:0010951 [negative regulation of endopeptidase activity] GO:0043234 [protein complex] GO:0070062 [extracellular exosome] GO:0071470 [cellular response to osmotic stress] Show all	376 aa 42.6 kDa	No	0
SERPINB6-201 ENSP00000484343 ENST00000612421	A0A087X1N8 [Direct mapping] Serpin B6; Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_e Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] Show all	395 aa 44.8 kDa	No	0
SERPINB6-202 ENSP00000481398 ENST00000616722	A0A024QZX5 [Direct mapping] Serpin B6; Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_d Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] Show all	380 aa 43 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.