Expression of PEX6 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Peroxisomal biogenesis factor 6

Protein class

Disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA025924

GENE INFORMATION
Gene name	PEX6 (HGNC Symbol)
Synonyms	PAF-2, PXAAA1
Description	Peroxisomal biogenesis factor 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) family of ATPases. This member is a predominantly cytoplasmic protein, which plays a direct role in peroxisomal protein import and is required for PTS1 (peroxisomal targeting signal 1, a C-terminal tripeptide of the sequence ser-lys-leu) receptor activity. Mutations in this gene cause peroxisome biogenesis disorders of complementation group 4 and complementation group 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	42963870 - 42979220
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124587 (version 83.38)
Entrez gene	5190
UniProt	Q13608 (UniProt - Evidence at protein level)
neXtProt	NX_Q13608
Antibodypedia	PEX6 antibodies

PROTEIN BROWSER

PEX6-001	PEX6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PEX6-001 ENSP00000303511 ENST00000304611	Q13608 [Direct mapping] Peroxisome assembly factor 2 A0A024RD09 [Target identity:100%; Query identity:100%] Peroxisomal biogenesis factor 6, isoform CRA_a Show all	Transporters Primary Active Transporters SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005829 [cytosol] GO:0006625 [protein targeting to peroxisome] GO:0007031 [peroxisome organization] GO:0008022 [protein C-terminus binding] GO:0016561 [protein import into peroxisome matrix, translocation] GO:0016887 [ATPase activity] GO:0032403 [protein complex binding] GO:0042623 [ATPase activity, coupled] GO:0050821 [protein stabilization] Show all	980 aa 104.1 kDa	No	0
PEX6-201 ENSP00000244546 ENST00000244546	Q13608 [Direct mapping] Peroxisome assembly factor 2 Show all	Transporters Primary Active Transporters SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005829 [cytosol] GO:0006625 [protein targeting to peroxisome] GO:0007031 [peroxisome organization] GO:0008022 [protein C-terminus binding] GO:0016561 [protein import into peroxisome matrix, translocation] GO:0016887 [ATPase activity] GO:0032403 [protein complex binding] GO:0042623 [ATPase activity, coupled] GO:0050821 [protein stabilization] Show all	738 aa 77.7 kDa	No	0