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AARS2

GENERAL INFORMATION

Gene name

 AARS2

Gene description

 Alanyl-tRNA synthetase 2, mitochondrial

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA035636
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 AARS2 (HGNC Symbol)

Synonyms

 AARSL, bA444E17.1, KIAA1270

Description

 Alanyl-tRNA synthetase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8. [provided by RefSeq, Dec 2011]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 44299654 - 44313326

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124608 (version 83.38)

Entrez gene

 57505

UniProt

 Q5JTZ9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5JTZ9

Antibodypedia

 AARS2 antibodies

PROTEIN BROWSER
AARS2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AARS2-001
ENSP00000244571
ENST00000244571
Q5JTZ9 [Direct mapping]
Alanine--tRNA ligase, mitochondrial
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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0004813 [alanine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006400 [tRNA modification]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006419 [alanyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0016597 [amino acid binding]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0033108 [mitochondrial respiratory chain complex assembly]
GO:0043039 [tRNA aminoacylation]
GO:0046872 [metal ion binding]
GO:0070143 [mitochondrial alanyl-tRNA aminoacylation]
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 985 aa
107.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.