Tissue expression of MED20 - Summary - The Human Protein Atlas

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MED20

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MED20
Gene description	Mediator complex subunit 20
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA040717
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MED20 (HGNC Symbol)
Synonyms	DKFZp586D2223, PRO0213, TRFP
Description	Mediator complex subunit 20 (HGNC Symbol)
Entrez gene summary	This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. A mutation in this gene has been associated with a novel infantile-onset neurodegenerative movement disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	41905354 - 41921139
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124641 (version 83.38)
Entrez gene	9477
UniProt	Q9H944 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H944
Antibodypedia	MED20 antibodies

PROTEIN BROWSER

MED20-001	MED20-003	MED20-004	MED20-005	MED20-007	MED20-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MED20-001 ENSP00000265350 ENST00000265350	Q9H944 [Direct mapping] Mediator of RNA polymerase II transcription subunit 20 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016567 [protein ubiquitination] GO:0016592 [mediator complex] GO:0061630 [ubiquitin protein ligase activity] Show all	212 aa 23.2 kDa	No	0
MED20-003 ENSP00000386668 ENST00000409060	B7ZBQ3 [Direct mapping] Mediator of RNA polymerase II transcription subunit 20 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	145 aa 15.9 kDa	No	0
MED20-004 ENSP00000377795 ENST00000394251	A6PVP4 [Direct mapping] Mediator of RNA polymerase II transcription subunit 20 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	140 aa 15.3 kDa	No	0
MED20-005 ENSP00000403061 ENST00000434077	B7ZBQ1 [Direct mapping] Mediator of RNA polymerase II transcription subunit 20 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		61 aa 6.8 kDa	Yes	0
MED20-007 ENSP00000386816 ENST00000409312	Q9H944 [Direct mapping] Mediator of RNA polymerase II transcription subunit 20 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016592 [mediator complex] Show all	123 aa 13.5 kDa	No	0
MED20-201 ENSP00000484159 ENST00000613074	A0A087X1F4 [Direct mapping] Mediator of RNA polymerase II transcription subunit 20 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	211 aa 23.1 kDa	No	0

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