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NUP153

CANCER ATLAS

Gene description

 Nucleoporin 153kDa

Protein class

 Predicted intracellular proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA027896
HPA027897
HPA027898

GENE INFORMATION

Gene name

 NUP153 (HGNC Symbol)

Synonyms

 HNUP153

Description

 Nucleoporin 153kDa (HGNC Symbol)

Entrez gene summary

 Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Chromosome

 6

Cytoband

 p22.3

Chromosome location (bp)

 17615035 - 17706834

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124789 (version 83.38)

Entrez gene

 9972

UniProt

 P49790 (UniProt - Evidence at protein level)

neXtProt

 NX_P49790

Antibodypedia

 NUP153 antibodies

PROTEIN BROWSER
NUP153-001
NUP153-201
NUP153-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUP153-001
ENSP00000262077
ENST00000262077
P49790 [Direct mapping]
Nuclear pore complex protein Nup153
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0005215 [transporter activity]
GO:0005487 [nucleocytoplasmic transporter activity]
GO:0005515 [protein binding]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008033 [tRNA processing]
GO:0008270 [zinc ion binding]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0017056 [structural constituent of nuclear pore]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031965 [nuclear membrane]
GO:0034399 [nuclear periphery]
GO:0034605 [cellular response to heat]
GO:0042405 [nuclear inclusion body]
GO:0042802 [identical protein binding]
GO:0043495 [protein anchor]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044615 [nuclear pore nuclear basket]
GO:0046718 [viral entry into host cell]
GO:0046832 [negative regulation of RNA export from nucleus]
GO:0051028 [mRNA transport]
GO:0051292 [nuclear pore complex assembly]
GO:0055085 [transmembrane transport]
GO:0075732 [viral penetration into host nucleus]
GO:1900034 [regulation of cellular response to heat]
Show all
 1475 aa
153.9 kDa 		No 0
NUP153-201
ENSP00000444029
ENST00000537253
P49790 [Direct mapping]
Nuclear pore complex protein Nup153
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0005215 [transporter activity]
GO:0005487 [nucleocytoplasmic transporter activity]
GO:0005515 [protein binding]
GO:0005642 [annulate lamellae]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008033 [tRNA processing]
GO:0008139 [nuclear localization sequence binding]
GO:0008270 [zinc ion binding]
GO:0008536 [Ran GTPase binding]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0017056 [structural constituent of nuclear pore]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031965 [nuclear membrane]
GO:0034399 [nuclear periphery]
GO:0034605 [cellular response to heat]
GO:0042405 [nuclear inclusion body]
GO:0042802 [identical protein binding]
GO:0043234 [protein complex]
GO:0043495 [protein anchor]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044615 [nuclear pore nuclear basket]
GO:0046718 [viral entry into host cell]
GO:0046832 [negative regulation of RNA export from nucleus]
GO:0051028 [mRNA transport]
GO:0051292 [nuclear pore complex assembly]
GO:0055085 [transmembrane transport]
GO:0075732 [viral penetration into host nucleus]
GO:1900034 [regulation of cellular response to heat]
Show all
 1506 aa
157.3 kDa 		No 0
NUP153-202
ENSP00000478627
ENST00000613258
P49790 [Direct mapping]
Nuclear pore complex protein Nup153
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0005215 [transporter activity]
GO:0005487 [nucleocytoplasmic transporter activity]
GO:0005515 [protein binding]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008033 [tRNA processing]
GO:0008270 [zinc ion binding]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0017056 [structural constituent of nuclear pore]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031965 [nuclear membrane]
GO:0034399 [nuclear periphery]
GO:0034605 [cellular response to heat]
GO:0042405 [nuclear inclusion body]
GO:0042802 [identical protein binding]
GO:0043495 [protein anchor]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044615 [nuclear pore nuclear basket]
GO:0046718 [viral entry into host cell]
GO:0046832 [negative regulation of RNA export from nucleus]
GO:0051028 [mRNA transport]
GO:0051292 [nuclear pore complex assembly]
GO:0055085 [transmembrane transport]
GO:0075732 [viral penetration into host nucleus]
GO:1900034 [regulation of cellular response to heat]
Show all
 1433 aa
149.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.