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This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003746 [translation elongation factor activity] GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006414 [translational elongation] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006749 [glutathione metabolic process] GO:0008285 [negative regulation of cell proliferation] GO:0010467 [gene expression] GO:0043065 [positive regulation of apoptotic process] GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0070062 [extracellular exosome]
