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GOT2

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GENERAL INFORMATION

Gene name

 GOT2

Gene description

 Glutamic-oxaloacetic transaminase 2, mitochondrial

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 GOT2 (HGNC Symbol)

Synonyms

 KAT4, KATIV, mitAAT

Description

 Glutamic-oxaloacetic transaminase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

 Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

Chromosome

 16

Cytoband

 q21

Chromosome location (bp)

 58707131 - 58734357

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125166 (version 83.38)

Entrez gene

 2806

UniProt

 P00505 (UniProt - Evidence at protein level)

neXtProt

 NX_P00505

Antibodypedia

 GOT2 antibodies

PROTEIN BROWSER
GOT2-001
GOT2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GOT2-001
ENSP00000245206
ENST00000245206
P00505 [Direct mapping]
Aspartate aminotransferase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004069 [L-aspartate:2-oxoglutarate aminotransferase activity]
GO:0005543 [phospholipid binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006531 [aspartate metabolic process]
GO:0006532 [aspartate biosynthetic process]
GO:0006533 [aspartate catabolic process]
GO:0006536 [glutamate metabolic process]
GO:0008652 [cellular amino acid biosynthetic process]
GO:0009058 [biosynthetic process]
GO:0009986 [cell surface]
GO:0015908 [fatty acid transport]
GO:0016212 [kynurenine-oxoglutarate transaminase activity]
GO:0016597 [amino acid binding]
GO:0019470 [4-hydroxyproline catabolic process]
GO:0019550 [glutamate catabolic process to aspartate]
GO:0019551 [glutamate catabolic process to 2-oxoglutarate]
GO:0019899 [enzyme binding]
GO:0030170 [pyridoxal phosphate binding]
GO:0031406 [carboxylic acid binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043204 [perikaryon]
GO:0043209 [myelin sheath]
GO:0043234 [protein complex]
GO:0043648 [dicarboxylic acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045471 [response to ethanol]
GO:0070062 [extracellular exosome]
GO:0080130 [L-phenylalanine:2-oxoglutarate aminotransferase activity]
GO:0097052 [L-kynurenine metabolic process]
Show all
 430 aa
47.5 kDa 		Yes 0
GOT2-005
ENSP00000394100
ENST00000434819
P00505 [Direct mapping]
Aspartate aminotransferase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004069 [L-aspartate:2-oxoglutarate aminotransferase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006531 [aspartate metabolic process]
GO:0006533 [aspartate catabolic process]
GO:0006536 [glutamate metabolic process]
GO:0008652 [cellular amino acid biosynthetic process]
GO:0009058 [biosynthetic process]
GO:0015908 [fatty acid transport]
GO:0016212 [kynurenine-oxoglutarate transaminase activity]
GO:0019470 [4-hydroxyproline catabolic process]
GO:0030170 [pyridoxal phosphate binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045471 [response to ethanol]
GO:0070062 [extracellular exosome]
GO:0080130 [L-phenylalanine:2-oxoglutarate aminotransferase activity]
GO:0097052 [L-kynurenine metabolic process]
Show all
 387 aa
43 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.