Expression of ABCC4 in cancer - Summary

CANCER ATLAS

Gene description

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

Protein class

Plasma proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Renal cancer

STAINING SUMMARY

HPA002476

GENE INFORMATION
Gene name	ABCC4 (HGNC Symbol)
Synonyms	EST170205, MOAT-B, MOATB, MRP4
Description	ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Chromosome	13
Cytoband	q32.1
Chromosome location (bp)	95019829 - 95301446
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125257 (version 83.38)
Entrez gene	10257
UniProt	O15439 (UniProt - Evidence at protein level)
neXtProt	NX_O15439
Antibodypedia	ABCC4 antibodies

PROTEIN BROWSER

ABCC4-001	ABCC4-006	ABCC4-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCC4-001 ENSP00000366084 ENST00000376887	O15439 [Direct mapping] Multidrug resistance-associated protein 4 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002576 [platelet degranulation] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0007596 [blood coagulation] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity] GO:0016887 [ATPase activity] GO:0030168 [platelet activation] GO:0031088 [platelet dense granule membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] GO:0055114 [oxidation-reduction process] Show all	1325 aa 149.5 kDa	No	>9
ABCC4-006 ENSP00000442024 ENST00000536256	O15439 [Direct mapping] Multidrug resistance-associated protein 4 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002576 [platelet degranulation] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0007596 [blood coagulation] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity] GO:0016887 [ATPase activity] GO:0030168 [platelet activation] GO:0031088 [platelet dense granule membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] GO:0055114 [oxidation-reduction process] Show all	784 aa 88.1 kDa	No	6
ABCC4-007 ENSP00000487081 ENST00000629385	O15439 [Direct mapping] Multidrug resistance-associated protein 4 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002576 [platelet degranulation] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0007596 [blood coagulation] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016404 [15-hydroxyprostaglandin dehydrogenase (NAD+) activity] GO:0016887 [ATPase activity] GO:0030168 [platelet activation] GO:0031088 [platelet dense granule membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] GO:0055114 [oxidation-reduction process] Show all	859 aa 96.8 kDa	No	9