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Prostate caners and a majority of cases in colorectal, breast and female genital cancers showed distinct granular cytoplasmic staining. Remaining cancers generally showed positivity in fractions of cells or were negative.
GENE INFORMATION
Gene name
TM9SF2 (HGNC Symbol)
Synonyms
P76
Description
Transmembrane 9 superfamily member 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the transmembrane 9 superfamily. The encoded 76 kDa protein localizes to early endosomes in human cells. The encoded protein possesses a conserved and highly hydrophobic C-terminal domain which contains nine transmembrane domains. The protein may play a role in small molecule transport or act as an ion channel. A pseudogene associated with this gene is located on the X chromosome. [provided by RefSeq, Oct 2012]
