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IRF1

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GENERAL INFORMATION

Gene name

 IRF1

Gene description

 Interferon regulatory factor 1

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB011662
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & nucleoplasm.

Main location

 Nucleoplasm (supported), Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB011662 A-431 Nucleoplasm
Cytosol
CAB011662 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 IRF1 (HGNC Symbol)

Synonyms

 MAR

Description

 Interferon regulatory factor 1 (HGNC Symbol)

Entrez gene summary

 IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q31.1

Chromosome location (bp)

 132481609 - 132490798

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125347 (version 83.38)

Entrez gene

 3659

UniProt

 P10914 (UniProt - Evidence at protein level)

neXtProt

 NX_P10914

Antibodypedia

 IRF1 antibodies

PROTEIN BROWSER
IRF1-001
IRF1-002
IRF1-007
IRF1-008
IRF1-010
IRF1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IRF1-001
ENSP00000245414
ENST00000245414
P10914 [Direct mapping]
Interferon regulatory factor 1
Q6FHN8 [Target identity:100%; Query identity:100%]
IRF1 protein; Interferon regulatory factor 1; Interferon regulatory factor-1; cDNA, FLJ94683, Homo sapiens interferon regulatory factor 1 (IRF1), mRNA
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0000790 [nuclear chromatin]
GO:0000975 [regulatory region DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002819 [regulation of adaptive immune response]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007050 [cell cycle arrest]
GO:0007596 [blood coagulation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010468 [regulation of gene expression]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032481 [positive regulation of type I interferon production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0034124 [regulation of MyD88-dependent toll-like receptor signaling pathway]
GO:0035458 [cellular response to interferon-beta]
GO:0043374 [CD8-positive, alpha-beta T cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045084 [positive regulation of interleukin-12 biosynthetic process]
GO:0045088 [regulation of innate immune response]
GO:0045590 [negative regulation of regulatory T cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051607 [defense response to virus]
GO:0051726 [regulation of cell cycle]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0071260 [cellular response to mechanical stimulus]
GO:2000564 [regulation of CD8-positive, alpha-beta T cell proliferation]
Show all
 325 aa
36.5 kDa 		No 0
IRF1-002
ENSP00000405655
ENST00000437654
C9J9C5 [Direct mapping]
Interferon regulatory factor 1
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Predicted intracellular proteins
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0050776 [regulation of immune response]
Show all
 198 aa
22.7 kDa 		No 0
IRF1-007
ENSP00000473661
ENST00000476613
R4GNI0 [Direct mapping]
Interferon regulatory factor 1
Show all
Predicted intracellular proteins
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0050776 [regulation of immune response]
Show all
 118 aa
13.9 kDa 		No 0
IRF1-008
ENSP00000384406
ENST00000405885
P10914 [Direct mapping]
Interferon regulatory factor 1
Q6FHN8 [Target identity:100%; Query identity:100%]
IRF1 protein; Interferon regulatory factor 1; Interferon regulatory factor-1; cDNA, FLJ94683, Homo sapiens interferon regulatory factor 1 (IRF1), mRNA
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0000790 [nuclear chromatin]
GO:0000975 [regulatory region DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002819 [regulation of adaptive immune response]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007050 [cell cycle arrest]
GO:0007596 [blood coagulation]
GO:0008285 [negative regulation of cell proliferation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032481 [positive regulation of type I interferon production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0034124 [regulation of MyD88-dependent toll-like receptor signaling pathway]
GO:0035458 [cellular response to interferon-beta]
GO:0045088 [regulation of innate immune response]
GO:0045590 [negative regulation of regulatory T cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051607 [defense response to virus]
GO:0051726 [regulation of cell cycle]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0071260 [cellular response to mechanical stimulus]
GO:2000564 [regulation of CD8-positive, alpha-beta T cell proliferation]
Show all
 325 aa
36.5 kDa 		No 0
IRF1-010
ENSP00000396318
ENST00000458069
C9JD95 [Direct mapping]
Interferon regulatory factor 1
Show all
Predicted intracellular proteins
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0050776 [regulation of immune response]
Show all
 192 aa
21.9 kDa 		No 0
IRF1-201
ENSP00000480887
ENST00000613424
V9P921 [Direct mapping]
Interferon regulatory factor 1; Interferon regulatory factor 1 isoform d78
Show all
Predicted intracellular proteins
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0050776 [regulation of immune response]
Show all
 201 aa
22.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.