Tissue expression of GRK4 - Summary - The Human Protein Atlas

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GRK4

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GRK4
Gene description	G protein-coupled receptor kinase 4
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (testis)
GTEx:	Group enriched (testis, cerebellum)
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in spermatogonia and distinct expression in membrane under cilia in fallopian tube and airway epithelia.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA057023
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (testis, cerebellum)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	GRK4 (HGNC Symbol)
Synonyms	GPRK2L, GPRK4
Description	G protein-coupled receptor kinase 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	2963608 - 3040747
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125388 (version 83.38)
Entrez gene	2868
UniProt	P32298 (UniProt - Evidence at protein level)
neXtProt	NX_P32298
Antibodypedia	GRK4 antibodies

PROTEIN BROWSER

GRK4-001	GRK4-002	GRK4-004	GRK4-005	GRK4-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRK4-001 ENSP00000381129 ENST00000398052	P32298 [Direct mapping] G protein-coupled receptor kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0002029 [desensitization of G-protein coupled receptor protein signaling pathway] GO:0002031 [G-protein coupled receptor internalization] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004703 [G-protein coupled receptor kinase activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0007603 [phototransduction, visible light] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0030425 [dendrite] GO:0031623 [receptor internalization] GO:0043025 [neuronal cell body] GO:0050254 [rhodopsin kinase activity] GO:0097381 [photoreceptor disc membrane] Show all	578 aa 66.6 kDa	No	0
GRK4-002 ENSP00000381128 ENST00000398051	P32298 [Direct mapping] G protein-coupled receptor kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004703 [G-protein coupled receptor kinase activity] GO:0005524 [ATP binding] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0007603 [phototransduction, visible light] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0031623 [receptor internalization] GO:0097381 [photoreceptor disc membrane] Show all	500 aa 57.7 kDa	No	0
GRK4-004 ENSP00000421650 ENST00000503518	D6REW5 [Direct mapping] G protein-coupled receptor kinase 4 Show all	Predicted intracellular proteins Show all		84 aa 9.2 kDa	No	0
GRK4-005 ENSP00000264764 ENST00000345167	P32298 [Direct mapping] G protein-coupled receptor kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004703 [G-protein coupled receptor kinase activity] GO:0005524 [ATP binding] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0007603 [phototransduction, visible light] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0031623 [receptor internalization] GO:0097381 [photoreceptor disc membrane] Show all	546 aa 63 kDa	No	0
GRK4-012 ENSP00000427445 ENST00000504933	P32298 [Direct mapping] G protein-coupled receptor kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004703 [G-protein coupled receptor kinase activity] GO:0005524 [ATP binding] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0007603 [phototransduction, visible light] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0031623 [receptor internalization] GO:0097381 [photoreceptor disc membrane] Show all	532 aa 61.2 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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