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SRY (sex determining region Y)-box 9 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001158 [enhancer sequence-specific DNA binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001501 [skeletal system development] GO:0001502 [cartilage condensation] GO:0001503 [ossification] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001708 [cell fate specification] GO:0001837 [epithelial to mesenchymal transition] GO:0001894 [tissue homeostasis] GO:0001934 [positive regulation of protein phosphorylation] GO:0001942 [hair follicle development] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002062 [chondrocyte differentiation] GO:0002063 [chondrocyte development] GO:0002683 [negative regulation of immune system process] GO:0003170 [heart valve development] GO:0003179 [heart valve morphogenesis] GO:0003188 [heart valve formation] GO:0003203 [endocardial cushion morphogenesis] GO:0003413 [chondrocyte differentiation involved in endochondral bone morphogenesis] GO:0003415 [chondrocyte hypertrophy] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0004672 [protein kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0006334 [nucleosome assembly] GO:0006338 [chromatin remodeling] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006461 [protein complex assembly] GO:0007010 [cytoskeleton organization] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0007283 [spermatogenesis] GO:0007417 [central nervous system development] GO:0007507 [heart development] GO:0008013 [beta-catenin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008584 [male gonad development] GO:0010564 [regulation of cell cycle process] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010634 [positive regulation of epithelial cell migration] GO:0014032 [neural crest cell development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016337 [single organismal cell-cell adhesion] GO:0019100 [male germ-line sex determination] GO:0019933 [cAMP-mediated signaling] GO:0030154 [cell differentiation] GO:0030155 [regulation of cell adhesion] GO:0030198 [extracellular matrix organization] GO:0030238 [male sex determination] GO:0030279 [negative regulation of ossification] GO:0030502 [negative regulation of bone mineralization] GO:0030850 [prostate gland development] GO:0030857 [negative regulation of epithelial cell differentiation] GO:0030858 [positive regulation of epithelial cell differentiation] GO:0030879 [mammary gland development] GO:0030903 [notochord development] GO:0030916 [otic vesicle formation] GO:0031018 [endocrine pancreas development] GO:0032331 [negative regulation of chondrocyte differentiation] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032808 [lacrimal gland development] GO:0034236 [protein kinase A catalytic subunit binding] GO:0034504 [protein localization to nucleus] GO:0035019 [somatic stem cell population maintenance] GO:0035326 [enhancer binding] GO:0035622 [intrahepatic bile duct development] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043425 [bHLH transcription factor binding] GO:0043491 [protein kinase B signaling] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044798 [nuclear transcription factor complex] GO:0045165 [cell fate commitment] GO:0045595 [regulation of cell differentiation] GO:0045662 [negative regulation of myoblast differentiation] GO:0045732 [positive regulation of protein catabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046533 [negative regulation of photoreceptor cell differentiation] GO:0046982 [protein heterodimerization activity] GO:0048709 [oligodendrocyte differentiation] GO:0048873 [homeostasis of number of cells within a tissue] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0051216 [cartilage development] GO:0060008 [Sertoli cell differentiation] GO:0060009 [Sertoli cell development] GO:0060018 [astrocyte fate commitment] GO:0060041 [retina development in camera-type eye] GO:0060174 [limb bud formation] GO:0060221 [retinal rod cell differentiation] GO:0060350 [endochondral bone morphogenesis] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060487 [lung epithelial cell differentiation] GO:0060512 [prostate gland morphogenesis] GO:0060517 [epithelial cell proliferation involved in prostatic bud elongation] GO:0060532 [bronchus cartilage development] GO:0060534 [trachea cartilage development] GO:0060729 [intestinal epithelial structure maintenance] GO:0060784 [regulation of cell proliferation involved in tissue homeostasis] GO:0061036 [positive regulation of cartilage development] GO:0061046 [regulation of branching involved in lung morphogenesis] GO:0061138 [morphogenesis of a branching epithelium] GO:0061145 [lung smooth muscle development] GO:0070168 [negative regulation of biomineral tissue development] GO:0070371 [ERK1 and ERK2 cascade] GO:0070384 [Harderian gland development] GO:0071260 [cellular response to mechanical stimulus] GO:0071300 [cellular response to retinoic acid] GO:0071347 [cellular response to interleukin-1] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071504 [cellular response to heparin] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:0071599 [otic vesicle development] GO:0072034 [renal vesicle induction] GO:0072170 [metanephric tubule development] GO:0072189 [ureter development] GO:0072190 [ureter urothelium development] GO:0072193 [ureter smooth muscle cell differentiation] GO:0072197 [ureter morphogenesis] GO:0072289 [metanephric nephron tubule formation] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090103 [cochlea morphogenesis] GO:0090184 [positive regulation of kidney development] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0097157 [pre-mRNA intronic binding] GO:1901203 [positive regulation of extracellular matrix assembly] GO:2000020 [positive regulation of male gonad development] GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis] GO:2000741 [positive regulation of mesenchymal stem cell differentiation] GO:2000794 [regulation of epithelial cell proliferation involved in lung morphogenesis] GO:2001054 [negative regulation of mesenchymal cell apoptotic process]