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MYH2

GENERAL INFORMATION

Gene name

 MYH2

Gene description

 Myosin, heavy chain 2, skeletal muscle, adult

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (skeletal muscle)
GTEx:Tissue enriched (skeletal muscle)
FANTOM5:Tissue enriched (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression mainly in skeletal muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA001349 , CAB010760
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)

GENE INFORMATION

Gene name

 MYH2 (HGNC Symbol)

Synonyms

 IBM3, MYH2A, MYHas8, MyHC-2A, MyHC-IIa, MYHSA2

Description

 Myosin, heavy chain 2, skeletal muscle, adult (HGNC Symbol)

Entrez gene summary

 Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 10521148 - 10549957

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125414 (version 83.38)

Entrez gene

 4620

UniProt

 Q9UKX2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKX2

Antibodypedia

 MYH2 antibodies

PROTEIN BROWSER
MYH2-001
MYH2-002
MYH2-006
MYH2-009
MYH2-201
MYH2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYH2-001
ENSP00000245503
ENST00000245503
Q9UKX2 [Direct mapping]
Myosin-2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0001778 [plasma membrane repair]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005826 [actomyosin contractile ring]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0005911 [cell-cell junction]
GO:0006936 [muscle contraction]
GO:0008152 [metabolic process]
GO:0014823 [response to activity]
GO:0016459 [myosin complex]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0031672 [A band]
GO:0032982 [myosin filament]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0061024 [membrane organization]
GO:0070252 [actin-mediated cell contraction]
Show all
 1941 aa
223 kDa 		No 0
MYH2-002
ENSP00000399348
ENST00000420805
E7EX84 [Direct mapping]
Myosin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 182 aa
20.7 kDa 		No 0
MYH2-006
ENSP00000433944
ENST00000532183
Q9UKX2 [Direct mapping]
Myosin-2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0006936 [muscle contraction]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0032982 [myosin filament]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0061024 [membrane organization]
Show all
 708 aa
79.9 kDa 		No 0
MYH2-009
ENSP00000463668
ENST00000578017
J3QLR0 [Direct mapping]
Myosin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 155 aa
17.6 kDa 		No 0
MYH2-201
ENSP00000380367
ENST00000397183
Q9UKX2 [Direct mapping]
Myosin-2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0006936 [muscle contraction]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0032982 [myosin filament]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0061024 [membrane organization]
Show all
 1941 aa
223 kDa 		No 0
MYH2-202
ENSP00000482463
ENST00000622564
Q9UKX2 [Direct mapping]
Myosin-2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0006936 [muscle contraction]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0032982 [myosin filament]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0061024 [membrane organization]
Show all
 708 aa
79.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.