Expression of NUP85 in cancer - Summary

CANCER ATLAS

Gene description

Nucleoporin 85kDa

Protein class

Predicted intracellular proteins, Predicted secreted proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA062595

GENE INFORMATION
Gene name	NUP85 (HGNC Symbol)
Synonyms	FLJ12549, NUP75
Description	Nucleoporin 85kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Chromosome	17
Cytoband	q25.1
Chromosome location (bp)	75205659 - 75235758
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125450 (version 83.38)
Entrez gene	79902
UniProt	Q9BW27 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BW27
Antibodypedia	NUP85 antibodies

PROTEIN BROWSER

NUP85-001	NUP85-002	NUP85-004	NUP85-006	NUP85-008	NUP85-011	NUP85-016	NUP85-023	NUP85-024	NUP85-025

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NUP85-001 ENSP00000245544 ENST00000245544	Q9BW27 [Direct mapping] Nuclear pore complex protein Nup85 Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000776 [kinetochore] GO:0000777 [condensed chromosome kinetochore] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006935 [chemotaxis] GO:0007077 [mitotic nuclear envelope disassembly] GO:0007264 [small GTPase mediated signal transduction] GO:0008033 [tRNA processing] GO:0008645 [hexose transport] GO:0010467 [gene expression] GO:0010827 [regulation of glucose transport] GO:0015031 [protein transport] GO:0015758 [glucose transport] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016925 [protein sumoylation] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019054 [modulation by virus of host process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0019221 [cytokine-mediated signaling pathway] GO:0030032 [lamellipodium assembly] GO:0031047 [gene silencing by RNA] GO:0031080 [nuclear pore outer ring] GO:0031965 [nuclear membrane] GO:0034605 [cellular response to heat] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0048246 [macrophage chemotaxis] GO:0051028 [mRNA transport] GO:0055085 [transmembrane transport] GO:1900034 [regulation of cellular response to heat] Show all	656 aa 75 kDa	No	0
NUP85-002 ENSP00000463382 ENST00000579324	J3QL54 [Direct mapping] Nuclear pore complex protein Nup85 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		544 aa 62.1 kDa	No	0
NUP85-004 ENSP00000462749 ENST00000579298	J3KT10 [Direct mapping] Nuclear pore complex protein Nup85 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		611 aa 70.2 kDa	No	0
NUP85-006 ENSP00000445855 ENST00000540768	F5H0W7 [Direct mapping] Nuclear pore complex protein Nup85 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		259 aa 29.9 kDa	No	0
NUP85-008 ENSP00000462487 ENST00000583569	J3KSH3 [Direct mapping] Nuclear pore complex protein Nup85 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		120 aa 13.8 kDa	No	0
NUP85-011 ENSP00000463715 ENST00000583877	J3QLV0 [Direct mapping] Nuclear pore complex protein Nup85 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		191 aa 21.7 kDa	No	0
NUP85-016 ENSP00000463542 ENST00000583070	J3QLH0 [Direct mapping] Nuclear pore complex protein Nup85 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		302 aa 34.7 kDa	No	0
NUP85-023 ENSP00000462364 ENST00000579838	J3KS87 [Direct mapping] Nuclear pore complex protein Nup85 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 11.1 kDa	No	0
NUP85-024 ENSP00000463437 ENST00000579900	J3QL91 [Direct mapping] Nuclear pore complex protein Nup85 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		114 aa 13.3 kDa	Yes	0
NUP85-025 ENSP00000463496 ENST00000579557	J3QLD4 [Direct mapping] Nuclear pore complex protein Nup85 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		272 aa 31 kDa	No	0