Cell atlas - MBOAT7 - The Human Protein Atlas

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MBOAT7

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	MBOAT7
Gene description	Membrane bound O-acyltransferase domain containing 7
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA055967
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA055967	A549	No staining
	HPA055967	RT4	Cytosol

GENE INFORMATION
Gene name	MBOAT7 (HGNC Symbol)
Synonyms	BB1, hMBOA-7, LENG4, LPIAT
Description	Membrane bound O-acyltransferase domain containing 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the reacylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Chromosome	19
Cytoband	q13.42
Chromosome location (bp)	54173412 - 54189882
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125505 (version 83.38)
Entrez gene	79143
UniProt	Q96N66 (UniProt - Evidence at protein level)
neXtProt	NX_Q96N66
Antibodypedia	MBOAT7 antibodies

PROTEIN BROWSER

MBOAT7-001	MBOAT7-002	MBOAT7-004	MBOAT7-005	MBOAT7-008	MBOAT7-012	MBOAT7-013	MBOAT7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MBOAT7-001 ENSP00000245615 ENST00000245615	Q96N66 [Direct mapping] Lysophospholipid acyltransferase 7 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0021591 [ventricular system development] GO:0021819 [layer formation in cerebral cortex] GO:0036149 [phosphatidylinositol acyl-chain remodeling] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0046488 [phosphatidylinositol metabolic process] GO:0071617 [lysophospholipid acyltransferase activity] Show all	472 aa 52.8 kDa	No	8
MBOAT7-002 ENSP00000375634 ENST00000391754	Q96N66 [Direct mapping] Lysophospholipid acyltransferase 7 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0036149 [phosphatidylinositol acyl-chain remodeling] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	344 aa 38.5 kDa	No	6
MBOAT7-004 ENSP00000388250 ENST00000414665	A9C4B8 [Direct mapping] Lysophospholipid acyltransferase 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	256 aa 28.6 kDa	No	5
MBOAT7-005 ENSP00000472209 ENST00000495279	M0R1Z5 [Direct mapping] Lysophospholipid acyltransferase 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	181 aa 19.8 kDa	No	3
MBOAT7-008 ENSP00000410320 ENST00000453320	C9J4E9 [Direct mapping] Lysophospholipid acyltransferase 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	170 aa 18.5 kDa	No	1
MBOAT7-012 ENSP00000406794 ENST00000449249	H7C2M4 [Direct mapping] Lysophospholipid acyltransferase 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		123 aa 13.3 kDa	Yes	1
MBOAT7-013 ENSP00000344377 ENST00000338624	Q96N66 [Direct mapping] Lysophospholipid acyltransferase 7 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0036149 [phosphatidylinositol acyl-chain remodeling] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	399 aa 44.7 kDa	No	5
MBOAT7-201 ENSP00000410503 ENST00000431666	Q96N66 [Direct mapping] Lysophospholipid acyltransferase 7 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0036149 [phosphatidylinositol acyl-chain remodeling] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	399 aa 44.7 kDa	No	5

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.