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OPRL1

GENERAL INFORMATION

Gene name

 OPRL1

Gene description

 Opiate receptor-like 1

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Mixed
FANTOM5:Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION

Gene name

 OPRL1 (HGNC Symbol)

Synonyms

 KOR-3, NOCIR, OOR, ORL1

Description

 Opiate receptor-like 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2011]

Chromosome

 20

Cytoband

 q13.33

Chromosome location (bp)

 64080173 - 64100643

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125510 (version 83.38)

Entrez gene

 4987

UniProt

 P41146 (UniProt - Evidence at protein level)

neXtProt

 NX_P41146

Antibodypedia

 OPRL1 antibodies

PROTEIN BROWSER
OPRL1-001
OPRL1-002
OPRL1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OPRL1-001
ENSP00000347848
ENST00000355631
P41146 [Direct mapping]
Nociceptin receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0001626 [nociceptin receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007600 [sensory perception]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019233 [sensory perception of pain]
GO:0038003 [opioid receptor signaling pathway]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
Show all
 370 aa
40.7 kDa 		No 7
OPRL1-002
ENSP00000336843
ENST00000336866
P41146 [Direct mapping]
Nociceptin receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0001626 [nociceptin receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007600 [sensory perception]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019233 [sensory perception of pain]
GO:0038003 [opioid receptor signaling pathway]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
Show all
 370 aa
40.7 kDa 		No 7
OPRL1-003
ENSP00000336764
ENST00000349451
P41146 [Direct mapping]
Nociceptin receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0001626 [nociceptin receptor activity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007600 [sensory perception]
GO:0008022 [protein C-terminus binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019233 [sensory perception of pain]
GO:0030817 [regulation of cAMP biosynthetic process]
GO:0030818 [negative regulation of cAMP biosynthetic process]
GO:0032355 [response to estradiol]
GO:0035810 [positive regulation of urine volume]
GO:0038003 [opioid receptor signaling pathway]
GO:0042755 [eating behavior]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0044849 [estrous cycle]
GO:0045776 [negative regulation of blood pressure]
GO:0051930 [regulation of sensory perception of pain]
GO:0060454 [positive regulation of gastric acid secretion]
GO:1901386 [negative regulation of voltage-gated calcium channel activity]
GO:1904058 [positive regulation of sensory perception of pain]
GO:1904059 [regulation of locomotor rhythm]
Show all
 370 aa
40.7 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.