Cell atlas - GRIA3 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

GRIA3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	GRIA3
Gene description	Glutamate receptor, ionotropic, AMPA 3
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Membrane,Secreted
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (BJ hTERT+, BJ, U-2197, U-87 MG, U-138 MG, hTCEpi)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (BJ hTERT+, BJ, U-2197, U-87 MG, U-138 MG, hTCEpi) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	GRIA3 (HGNC Symbol)
Synonyms	GluA3, GLUR3, GLURC, MRX94
Description	Glutamate receptor, ionotropic, AMPA 3 (HGNC Symbol)
Entrez gene summary	Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q25
Chromosome location (bp)	123184153 - 123490915
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125675 (version 83.38)
Entrez gene	2892
UniProt	P42263 (UniProt - Evidence at protein level)
neXtProt	NX_P42263
Antibodypedia	GRIA3 antibodies

PROTEIN BROWSER

GRIA3-001	GRIA3-002	GRIA3-006	GRIA3-007	GRIA3-201	GRIA3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRIA3-001 ENSP00000478489 ENST00000620443	P42263 [Direct mapping] Glutamate receptor 3 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004970 [ionotropic glutamate receptor activity] GO:0004971 [AMPA glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0007215 [glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0030666 [endocytic vesicle membrane] GO:0032281 [AMPA glutamate receptor complex] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035249 [synaptic transmission, glutamatergic] GO:0045211 [postsynaptic membrane] Show all	894 aa 101.2 kDa	Yes	3
GRIA3-002 ENSP00000446440 ENST00000541091	P42263 [Direct mapping] Glutamate receptor 3 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0004970 [ionotropic glutamate receptor activity] GO:0004971 [AMPA glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0007215 [glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0030666 [endocytic vesicle membrane] GO:0032281 [AMPA glutamate receptor complex] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035249 [synaptic transmission, glutamatergic] GO:0045211 [postsynaptic membrane] Show all	894 aa 101.2 kDa	Yes	3
GRIA3-006 ENSP00000478758 ENST00000611689	Q5XKG2 [Direct mapping] Glutamate receptor 3; Glutamate receptor, ionotrophic, AMPA 3 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0030425 [dendrite] GO:0032281 [AMPA glutamate receptor complex] GO:0034220 [ion transmembrane transport] GO:0035249 [synaptic transmission, glutamatergic] GO:0045211 [postsynaptic membrane] Show all	144 aa 16.1 kDa	Yes	0
GRIA3-007 ENSP00000479607 ENST00000616590	Q5XKG2 [Direct mapping] Glutamate receptor 3; Glutamate receptor, ionotrophic, AMPA 3 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0030425 [dendrite] GO:0032281 [AMPA glutamate receptor complex] GO:0034220 [ion transmembrane transport] GO:0035249 [synaptic transmission, glutamatergic] GO:0045211 [postsynaptic membrane] Show all	144 aa 16.1 kDa	Yes	0
GRIA3-201 ENSP00000481875 ENST00000620581	A0A087WYJ6 [Direct mapping] Glutamate receptor 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004970 [ionotropic glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0016020 [membrane] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0032281 [AMPA glutamate receptor complex] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035249 [synaptic transmission, glutamatergic] GO:0045211 [postsynaptic membrane] Show all	824 aa 93.4 kDa	Yes	2
GRIA3-202 ENSP00000481554 ENST00000622768	P42263 [Direct mapping] Glutamate receptor 3 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004970 [ionotropic glutamate receptor activity] GO:0004971 [AMPA glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0007215 [glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0030666 [endocytic vesicle membrane] GO:0032279 [asymmetric synapse] GO:0032281 [AMPA glutamate receptor complex] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035249 [synaptic transmission, glutamatergic] GO:0043025 [neuronal cell body] GO:0043083 [synaptic cleft] GO:0043195 [terminal bouton] GO:0043197 [dendritic spine] GO:0043198 [dendritic shaft] GO:0043204 [perikaryon] GO:0045211 [postsynaptic membrane] GO:0060992 [response to fungicide] Show all	894 aa 101.2 kDa	Yes	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.