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Gene name

Class

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Chromosome

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In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

Tissue

Cell type

Expression

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Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

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Score

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Antibodies

Column

 
 
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MED1
  • TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

MED1

Gene description

Mediator complex subunit 1

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB017696
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

MED1 (HGNC Symbol)

Synonyms

CRSP1, CRSP200, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2

Description

Mediator complex subunit 1 (HGNC Symbol)

Entrez gene summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q12

Chromosome location (bp)

39404285 - 39451286

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125686 (version 83.38)

Entrez gene

5469

UniProt

Q15648 (UniProt - Evidence at protein level)

neXtProt

NX_Q15648

Antibodypedia

MED1 antibodies

PROTEIN BROWSER

MED1-001
MED1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MED1-001
ENSP00000300651
ENST00000300651
Q15648 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000151 [ubiquitin ligase complex]
GO:0000785 [chromatin]
GO:0000902 [cell morphogenesis]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0001525 [angiogenesis]
GO:0001701 [in utero embryonic development]
GO:0001889 [liver development]
GO:0001892 [embryonic placenta development]
GO:0002088 [lens development in camera-type eye]
GO:0002154 [thyroid hormone mediated signaling pathway]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003406 [retinal pigment epithelium development]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003712 [transcription cofactor activity]
GO:0003713 [transcription coactivator activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006356 [regulation of transcription from RNA polymerase I promoter]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006590 [thyroid hormone generation]
GO:0006702 [androgen biosynthetic process]
GO:0007275 [multicellular organismal development]
GO:0007420 [brain development]
GO:0007507 [heart development]
GO:0007595 [lactation]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0009887 [organ morphogenesis]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0016020 [membrane]
GO:0016567 [protein ubiquitination]
GO:0016592 [mediator complex]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0030216 [keratinocyte differentiation]
GO:0030224 [monocyte differentiation]
GO:0030331 [estrogen receptor binding]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030375 [thyroid hormone receptor coactivator activity]
GO:0030518 [intracellular steroid hormone receptor signaling pathway]
GO:0030521 [androgen receptor signaling pathway]
GO:0031100 [organ regeneration]
GO:0031490 [chromatin DNA binding]
GO:0032403 [protein complex binding]
GO:0032993 [protein-DNA complex]
GO:0033148 [positive regulation of intracellular estrogen receptor signaling pathway]
GO:0033160 [positive regulation of protein import into nucleus, translocation]
GO:0033598 [mammary gland epithelial cell proliferation]
GO:0033601 [positive regulation of mammary gland epithelial cell proliferation]
GO:0035050 [embryonic heart tube development]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0035162 [embryonic hemopoiesis]
GO:0035257 [nuclear hormone receptor binding]
GO:0035357 [peroxisome proliferator activated receptor signaling pathway]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0035855 [megakaryocyte development]
GO:0036033 [mediator complex binding]
GO:0042789 [mRNA transcription from RNA polymerase II promoter]
GO:0042809 [vitamin D receptor binding]
GO:0042974 [retinoic acid receptor binding]
GO:0042975 [peroxisome proliferator activated receptor binding]
GO:0043010 [camera-type eye development]
GO:0043066 [negative regulation of apoptotic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045444 [fat cell differentiation]
GO:0045618 [positive regulation of keratinocyte differentiation]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046966 [thyroid hormone receptor binding]
GO:0048821 [erythrocyte development]
GO:0048822 [enucleate erythrocyte development]
GO:0050693 [LBD domain binding]
GO:0051726 [regulation of cell cycle]
GO:0060335 [positive regulation of interferon-gamma-mediated signaling pathway]
GO:0060744 [mammary gland branching involved in thelarche]
GO:0060745 [mammary gland branching involved in pregnancy]
GO:0060750 [epithelial cell proliferation involved in mammary gland duct elongation]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070318 [positive regulation of G0 to G1 transition]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070562 [regulation of vitamin D receptor signaling pathway]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:2000273 [positive regulation of receptor activity]
GO:2000347 [positive regulation of hepatocyte proliferation]
GO:2001141 [regulation of RNA biosynthetic process]
Show all
1581 aa
168.5 kDa
No 0
MED1-002
ENSP00000377828
ENST00000394287
Q15648 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000902 [cell morphogenesis]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0001525 [angiogenesis]
GO:0002088 [lens development in camera-type eye]
GO:0002154 [thyroid hormone mediated signaling pathway]
GO:0003682 [chromatin binding]
GO:0003712 [transcription cofactor activity]
GO:0003713 [transcription coactivator activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006356 [regulation of transcription from RNA polymerase I promoter]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006702 [androgen biosynthetic process]
GO:0008134 [transcription factor binding]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0016020 [membrane]
GO:0016592 [mediator complex]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0030216 [keratinocyte differentiation]
GO:0030331 [estrogen receptor binding]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030375 [thyroid hormone receptor coactivator activity]
GO:0030518 [intracellular steroid hormone receptor signaling pathway]
GO:0030521 [androgen receptor signaling pathway]
GO:0035257 [nuclear hormone receptor binding]
GO:0035855 [megakaryocyte development]
GO:0036033 [mediator complex binding]
GO:0042789 [mRNA transcription from RNA polymerase II promoter]
GO:0042809 [vitamin D receptor binding]
GO:0042974 [retinoic acid receptor binding]
GO:0042975 [peroxisome proliferator activated receptor binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045444 [fat cell differentiation]
GO:0045618 [positive regulation of keratinocyte differentiation]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046966 [thyroid hormone receptor binding]
GO:0048821 [erythrocyte development]
GO:0050693 [LBD domain binding]
GO:0051726 [regulation of cell cycle]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:2000273 [positive regulation of receptor activity]
GO:2001141 [regulation of RNA biosynthetic process]
Show all
556 aa
61.6 kDa
No 0

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  • INTRODUCTION
  • ORGANIZATION
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  • LICENCE & CITATION
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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.