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ATG4C

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GENERAL INFORMATION

Gene name

 ATG4C

Gene description

 Autophagy related 4C, cysteine peptidase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA007049
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & nucleoplasm.

Main location

 Nucleoplasm (approved), Cytosol (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA007049 A-431 Nucleoplasm
Cytosol
HPA007049 U-2 OS Nucleoplasm
Cytosol
HPA007049 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 ATG4C (HGNC Symbol)

Synonyms

 APG4C, AUTL1, AUTL3, FLJ14867

Description

 Autophagy related 4C, cysteine peptidase (HGNC Symbol)

Entrez gene summary

 Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p31.3

Chromosome location (bp)

 62784135 - 62865513

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125703 (version 83.38)

Entrez gene

 84938

UniProt

 Q96DT6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96DT6

Antibodypedia

 ATG4C antibodies

PROTEIN BROWSER
ATG4C-001
ATG4C-002
ATG4C-003
ATG4C-004
ATG4C-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATG4C-001
ENSP00000322159
ENST00000317868
Q96DT6 [Direct mapping]
Cysteine protease ATG4C
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006508 [proteolysis]
GO:0006612 [protein targeting to membrane]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008233 [peptidase activity]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 458 aa
52.5 kDa 		No 0
ATG4C-002
ENSP00000360161
ENST00000371120
Q96DT6 [Direct mapping]
Cysteine protease ATG4C
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006508 [proteolysis]
GO:0006612 [protein targeting to membrane]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008233 [peptidase activity]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 458 aa
52.5 kDa 		No 0
ATG4C-003
ENSP00000396614
ENST00000443289
C9JC51 [Direct mapping]
Cysteine protease ATG4C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000422 [mitophagy]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008234 [cysteine-type peptidase activity]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 151 aa
17.4 kDa 		No 0
ATG4C-004
ENSP00000360159
ENST00000371118
A6NGQ4 [Direct mapping]
Cysteine protease ATG4C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000422 [mitophagy]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008234 [cysteine-type peptidase activity]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 189 aa
21.7 kDa 		No 0
ATG4C-005
ENSP00000391820
ENST00000414558
H7BZW5 [Direct mapping]
Cysteine protease ATG4C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000422 [mitophagy]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008234 [cysteine-type peptidase activity]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 110 aa
12.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.