Cell atlas - CD70 - The Human Protein Atlas

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CD70

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CD70
Gene description	CD70 molecule
Protein class	Cancer-related genes CD markers Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (U-266/70, U-266/84, SiHa, U-251 MG)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA046582
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70, U-266/84, SiHa, U-251 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046582	SiHa	Nucleoplasm
	HPA046582	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	CD70 (HGNC Symbol)
Synonyms	CD27L, CD27LG, TNFSF7
Description	CD70 molecule (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	6583183 - 6604103
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125726 (version 83.38)
Entrez gene	970
UniProt	P32970 (UniProt - Evidence at protein level)
neXtProt	NX_P32970
Antibodypedia	CD70 antibodies

PROTEIN BROWSER

CD70-001	CD70-002	CD70-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD70-001 ENSP00000245903 ENST00000245903	P32970 [Direct mapping] CD70 antigen Show all	CD markers MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0005102 [receptor binding] GO:0005125 [cytokine activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0070062 [extracellular exosome] GO:0097191 [extrinsic apoptotic signaling pathway] Show all	193 aa 21.1 kDa	No	0
CD70-002 ENSP00000470805 ENST00000597430	M0QZW2 [Direct mapping] CD70 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	65 aa 7.1 kDa	No	1
CD70-003 ENSP00000395294 ENST00000423145	P32970 [Direct mapping] CD70 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0005102 [receptor binding] GO:0005125 [cytokine activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0070062 [extracellular exosome] GO:0097191 [extrinsic apoptotic signaling pathway] Show all	208 aa 23.4 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.