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A majority of malignant tissues showed moderate to strong cytoplasmic and occasional membranous staining. Skin and head and neck cancers along with malignant glioma, melanoma and lymphoma were in general negative.
GENE INFORMATION
Gene name
TNFSF14 (HGNC Symbol)
Synonyms
CD258, HVEM-L, LIGHT, LTg
Description
Tumor necrosis factor (ligand) superfamily, member 14 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]