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VASP

GENERAL INFORMATION

Gene name

 VASP

Gene description

 Vasodilator-stimulated phosphoprotein

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA005724 , CAB004612
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 VASP

Synonyms

Description

 Vasodilator-stimulated phosphoprotein (HGNC Symbol)

Entrez gene summary

 Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 45506579 - 45526983

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125753 (version 83.38)

Entrez gene

 7408

UniProt

 P50552 (UniProt - Evidence at protein level)

neXtProt

 NX_P50552

Antibodypedia

 VASP antibodies

PROTEIN BROWSER
VASP-001
VASP-004
VASP-011
VASP-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VASP-001
ENSP00000245932
ENST00000245932
P50552 [Direct mapping]
Vasodilator-stimulated phosphoprotein
A0A024R0V4 [Target identity:100%; Query identity:100%]
Vasodilator-stimulated phosphoprotein, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843 [neural tube closure]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0005925 [focal adhesion]
GO:0007411 [axon guidance]
GO:0008154 [actin polymerization or depolymerization]
GO:0015629 [actin cytoskeleton]
GO:0017124 [SH3 domain binding]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0030175 [filopodium]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031258 [lamellipodium membrane]
GO:0031527 [filopodium membrane]
GO:0034329 [cell junction assembly]
GO:0050852 [T cell receptor signaling pathway]
GO:0051289 [protein homotetramerization]
GO:0070062 [extracellular exosome]
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 380 aa
39.8 kDa 		No 0
VASP-004
ENSP00000467773
ENST00000590603
K7EQD0 [Direct mapping]
Vasodilator-stimulated phosphoprotein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 36 aa
3.6 kDa 		No 0
VASP-011
ENSP00000467061
ENST00000589627
K7ENR7 [Direct mapping]
Vasodilator-stimulated phosphoprotein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005856 [cytoskeleton]
GO:0008154 [actin polymerization or depolymerization]
GO:0017124 [SH3 domain binding]
GO:0051289 [protein homotetramerization]
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 59 aa
6.6 kDa 		No 0
VASP-012
ENSP00000464742
ENST00000592139
K7EIG8 [Direct mapping]
Vasodilator-stimulated phosphoprotein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005856 [cytoskeleton]
GO:0008154 [actin polymerization or depolymerization]
GO:0017124 [SH3 domain binding]
GO:0051289 [protein homotetramerization]
Show all
 46 aa
5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.