Cell atlas - SDCBP2 - The Human Protein Atlas

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SDCBP2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Vesicles

Human cell
	Cytosol
	Vesicles

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GENERAL INFORMATION
Gene name	SDCBP2
Gene description	Syndecan binding protein (syntenin) 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (CAPAN-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA054554
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the cytosol.

Main location

Vesicles (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA054554	A-431	Vesicles
	HPA054554	A-431	Cytosol
	HPA054554	RT4	Vesicles
	HPA054554	U-2 OS	Vesicles

GENE INFORMATION
Gene name	SDCBP2 (HGNC Symbol)
Synonyms	SITAC18, ST-2
Description	Syndecan binding protein (syntenin) 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	1309909 - 1329239
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125775 (version 83.38)
Entrez gene	27111
UniProt	Q9H190 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H190
Antibodypedia	SDCBP2 antibodies

PROTEIN BROWSER

SDCBP2-001	SDCBP2-002	SDCBP2-003	SDCBP2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SDCBP2-001 ENSP00000371233 ENST00000381812	Q9H190 [Direct mapping] Syntenin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007399 [nervous system development] GO:0008022 [protein C-terminus binding] GO:0035556 [intracellular signal transduction] GO:0042803 [protein homodimerization activity] GO:0046907 [intracellular transport] GO:0046982 [protein heterodimerization activity] GO:0070062 [extracellular exosome] Show all	292 aa 31.6 kDa	No	0
SDCBP2-002 ENSP00000371229 ENST00000381808	Q9H190 [Direct mapping] Syntenin-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007399 [nervous system development] GO:0008022 [protein C-terminus binding] GO:0035556 [intracellular signal transduction] GO:0042803 [protein homodimerization activity] GO:0046907 [intracellular transport] GO:0046982 [protein heterodimerization activity] GO:0070062 [extracellular exosome] Show all	207 aa 22.7 kDa	No	0
SDCBP2-003 ENSP00000354013 ENST00000360779	Q9H190 [Direct mapping] Syntenin-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007399 [nervous system development] GO:0008022 [protein C-terminus binding] GO:0035556 [intracellular signal transduction] GO:0042803 [protein homodimerization activity] GO:0046907 [intracellular transport] GO:0046982 [protein heterodimerization activity] GO:0070062 [extracellular exosome] Show all	292 aa 31.6 kDa	No	0
SDCBP2-004 ENSP00000342935 ENST00000339987	Q9H190 [Direct mapping] Syntenin-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007399 [nervous system development] GO:0008022 [protein C-terminus binding] GO:0035556 [intracellular signal transduction] GO:0042803 [protein homodimerization activity] GO:0046907 [intracellular transport] GO:0046982 [protein heterodimerization activity] GO:0070062 [extracellular exosome] Show all	292 aa 31.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.