Fields »
ABOUT
HELP
BLOG
PANK2

GENERAL INFORMATION

Gene name

 PANK2

Gene description

 Pantothenate kinase 2

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA008440
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PANK2 (HGNC Symbol)

Synonyms

 C20orf48, FLJ11729, HARP, HSS, NBIA1, PKAN

Description

 Pantothenate kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 3888839 - 3929882

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125779 (version 83.38)

Entrez gene

 80025

UniProt

 Q9BZ23 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BZ23

Antibodypedia

 PANK2 antibodies

PROTEIN BROWSER
PANK2-001
PANK2-003
PANK2-007
PANK2-008
PANK2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PANK2-001
ENSP00000417609
ENST00000497424
Q9BZ23 [Direct mapping]
Pantothenate kinase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004594 [pantothenate kinase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005758 [mitochondrial intermembrane space]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0009108 [coenzyme biosynthetic process]
GO:0015937 [coenzyme A biosynthetic process]
GO:0015939 [pantothenate metabolic process]
GO:0016310 [phosphorylation]
GO:0019217 [regulation of fatty acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0090207 [regulation of triglyceride metabolic process]
GO:1904251 [regulation of bile acid metabolic process]
Show all
 279 aa
30.8 kDa 		No 0
PANK2-003
ENSP00000476745
ENST00000495692
V9GYH1 [Direct mapping]
Pantothenate kinase 2, mitochondrial
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004594 [pantothenate kinase activity]
GO:0005524 [ATP binding]
GO:0015937 [coenzyme A biosynthetic process]
GO:0016310 [phosphorylation]
Show all
 115 aa
12.8 kDa 		No 0
PANK2-007
ENSP00000313377
ENST00000316562
Q9BZ23 [Direct mapping]
Pantothenate kinase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004594 [pantothenate kinase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005758 [mitochondrial intermembrane space]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0007286 [spermatid development]
GO:0009060 [aerobic respiration]
GO:0009108 [coenzyme biosynthetic process]
GO:0015937 [coenzyme A biosynthetic process]
GO:0015939 [pantothenate metabolic process]
GO:0016310 [phosphorylation]
GO:0019217 [regulation of fatty acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0070584 [mitochondrion morphogenesis]
GO:0090207 [regulation of triglyceride metabolic process]
GO:1904251 [regulation of bile acid metabolic process]
Show all
 570 aa
62.7 kDa 		No 0
PANK2-008
ENSP00000477429
ENST00000610179
Q9BZ23 [Direct mapping]
Pantothenate kinase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004594 [pantothenate kinase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005758 [mitochondrial intermembrane space]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0009108 [coenzyme biosynthetic process]
GO:0015937 [coenzyme A biosynthetic process]
GO:0015939 [pantothenate metabolic process]
GO:0016310 [phosphorylation]
GO:0019217 [regulation of fatty acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0090207 [regulation of triglyceride metabolic process]
GO:1904251 [regulation of bile acid metabolic process]
Show all
 447 aa
49.1 kDa 		No 0
PANK2-201
ENSP00000481523
ENST00000621507
Q9BZ23 [Direct mapping]
Pantothenate kinase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004594 [pantothenate kinase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005758 [mitochondrial intermembrane space]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0009108 [coenzyme biosynthetic process]
GO:0015937 [coenzyme A biosynthetic process]
GO:0015939 [pantothenate metabolic process]
GO:0016310 [phosphorylation]
GO:0019217 [regulation of fatty acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0090207 [regulation of triglyceride metabolic process]
GO:1904251 [regulation of bile acid metabolic process]
Show all
 279 aa
30.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.